Cytokines as markers for infections and their effect on growth performance and well-being in the pig
Cytokines as markers for infections and their effect on growth performance and well-being in the pig
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DOI：
10.1016/s0739-7240(98)80001-5
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发表时间：
1998-09-01
影响因子：
2.1
通讯作者：
Fossum, C
中科院分区：
文献类型：
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作者：
Fossum, C
接触微生物通常会引起细胞因子的产生。这些可溶性因子增强了多种先天免疫功能，旨在限制感染的传播。此外，许多促炎细胞因子调节随后的特异性免疫反应。除了对免疫系统细胞的影响外，细胞因子还是所谓的免疫神经内分泌网络中的重要调节剂。诱导细胞因子产生所需的微生物结构尚未最终确定，但一般来说，细菌优先诱导 IL-1、TNF-α、IL-6 和 IL-8 的产生，而病毒则诱导 1 型干扰素 (IFN-α/β) 的产生。这些细胞因子的产生速度很快，其中一些细胞因子可能在感染后短时间内达到全身水平。因此，细胞因子可以作为持续感染的标记物，并用于区分细菌或病毒来源的感染。实验和现场研究的结果表明，血清 IFN-a 和 IL-6 似乎分别是猪持续（亚临床）病毒和细菌感染的有用标记。因此，这些细胞因子的展示可以成为健康监测项目中的宝贵工具。 (C) 爱思唯尔科学公司 1998
Exposure to micro-organisms commonly elicit the production of cytokines. These soluble factors enhance several innate immune functions that aim to limit the spread of infection. Further, many of the pro-inflammatory cytokines regulate the ensuing specific immune response. In addition to their effects on cells of the immune system, cytokines also are important regulators in the so called immune-neuroendocrine network. The microbial structures that are necessary for induction of cytokine production are not conclusively determined but in general, bacteria preferentially induce the production of IL-1, TNF-alpha, IL-6, and IL-8, whereas virus induce the production of Type 1 interferons (IFN-alpha/beta). The onset of production of these cytokines is rapid, and several of them may reach systemic levels during a short period after infection. Thus, cytokines can Serve as markers for ongoing infections and be used for discrimination between infections of bacterial or viral origin. Results from experimental and field studies show that serum IFN-a and IL-6 seem to be useful markers for ongoing (subclinical) viral and bacterial infections, respectively, in the pig. Consequently, demonstration of these cytokines can be valuable tools in heard health monitoring programs. (C) Elsevier Science Inc. 1998