Induction of gene encoding FABP4 in Pten-null keratinocytes
Induction of gene encoding FABP4 in Pten-null keratinocytes
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DOI：
10.1016/j.febslet.2009.03.030
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发表时间：
2009-04-17
期刊：
影响因子：
3.5
通讯作者：
Manabe, Motomu
中科院分区：
文献类型：
--
作者：
Tsuda, Masaaki;Inoue-Narita, Tae;Manabe, Motomu
角质形成细胞特异性pten缺失小鼠显示出不同的表型，包括表皮和皮脂腺增生。为了确定促成其表型的候选基因，我们使用微阵列技术分析了Pten-null角质形成细胞的综合基因表达。结果表明，诱导最多的基因是脂肪细胞特异性脂肪酸结合蛋白（FABP4）。综上所述，可以想象FABP4通路介导了角质形成细胞特异性pten缺失小鼠的皮脂腺增生。(C) 2009年欧洲生化学会联合会。Elsevier B.V.版权所有。
Keratinocyte-specific Pten-null mice revealed distinct phenotypes, including epidermal and sebaceous gland hyperplasia. To determine the candidate genes that contribute to their phenotypes, we analyzed a comprehensive gene expression of Pten-null keratinocytes using microarray technology. Consequently, it was demonstrated that the most induced gene was adipocyte-specific fatty acid-binding protein (FABP4). Collectively, it is conceivable that the FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.