Mapping mental number line in physical space: Vertical and horizontal visual number line orientation in asymptomatic individuals with HIV
Mapping mental number line in physical space: Vertical and horizontal visual number line orientation in asymptomatic individuals with HIV
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DOI：
10.1016/j.neuropsychologia.2008.05.029
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发表时间：
2008-10-01
期刊：
影响因子：
2.6
通讯作者：
Cronin-Golomb, Alice
中科院分区：
文献类型：
--
作者：
Bogdanova, Yelena;Neargarder, Sandy;Cronin-Golomb, Alice
多项研究表明，人类免疫缺陷病毒（HIV）涉及额纹状体功能障碍，并描述了认知缺陷，重点是执行功能和记忆。值得注意的是，我们对HIV的视觉空间和数字处理知之甚少，尽管这些能力也得到了额纹状体回路及其顶叶连接的支持。我们调查了无症状HIV感染者的数字和空间认知的关系，并使用几种呈现和反应模式探索了身体和心理数字定向：心理数字线平分，物理线平分，以及视觉呈现的水平和垂直数字线上的物理数字线定向。无症状的HIV+组在视觉空间和数字处理任务上明显慢于HIV-组（n = 37/组），并且产生更多的错误。两组都显示出数字处理和视觉空间表现之间的显着相关性。这些发现表明，病程早期与艾滋病毒相关的脑损伤可以改变数字距离的空间表示，为艾滋病毒数字处理基础上的额纹回路及其顶叶投射的破坏提供了证据。除了与疾病相关的影响外，本研究还表明，物理数字线在垂直和水平物理维度上都保持了其数字和空间完整性，因为所有参与者都表现出对数字距离的低估，即水平偏差（水平呈现）和向下偏差（垂直）。我们的研究结果还揭示了数字距离和物理空间的处理组件之间的分离，表明参与数字线和物理线方向的神经网络之间的差异。(C)2008爱思唯尔有限公司保留所有权利。
Multiple studies have implicated frontostriatal dysfunction in human immunodeficiency virus (HIV) and described cognitive deficits with a focus on executive function and memory. Remarkably little is known about visuospatial and number processing in HIV, though these capacities are also supported by frontostriatal circuits and their parietal connections. We investigated the relation of numerical and spatial cognition in asymptomatic individuals with HIV and explored physical and mental number orientation using several modes of presentation and response: mental number line bisection, physical line bisection, and physical number line orientation on visually-presented horizontal and vertical number lines. The asymptomatic HIV+ group Was significantly slower and produced more errors on visuospatial and number processing tasks than the HIV- group (n = 37/group). Both groups showed significant correlations between number processing and visuospatial performance. These findings demonstrate that HIV-related brain damage early in the disease course can alter the spatial representation of numerical distance, providing evidence for disruption of frontostriatal circuits and their parietal projections underlying numerical processing in HIV. Besides disease-related effects, this Study demonstrates that the physical number line preserves its numerical and spatial integrity in both the vertical and horizontal physical dimensions, as all participants exhibited underestimation of numerical distance, i.e. leftward bias (for horizontal presentation) and downward bias (for vertical). Our results also revealed a dissociation between the processing components of numerical distance and physical space, suggesting differentiation between the neural networks involved in number lines and physical line orientation. (C) 2008 Elsevier Ltd. All rights reserved.