AC electroosmosis micromixing on a lab-on-a-foil electric microfluidic device
AC electroosmosis micromixing on a lab-on-a-foil electric microfluidic device
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DOI：
10.1016/j.snb.2022.131611
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发表时间：
2022-02
期刊：
影响因子：
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通讯作者：
Mengren Wu;Yuan Gao;A. Ghaznavi;Weiqi Zhao;Jie Xu
中科院分区：
文献类型：
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作者：
Mengren Wu;Yuan Gao;A. Ghaznavi;Weiqi Zhao;Jie Xu
芯片实验室设备中流体的有效混合对于许多生物医学和生化应用非常重要。箔上实验室作为一种新颖的概念，提供了一种基于薄膜和柔性薄膜材料的微流体装置的快速原型设计或大规模生产的方法。在本文中，电渗微混合是在箔片实验室微流体装置中进行的。利用电渗流（EOF），通过齿形平面电极在微通道内实现高效的微混合。混合性能根据强度测量进行评估，并使用扫频来确定最佳性能。此外，根据局部强度分布，分析 EOF 模式，以深入了解频率和流量的影响。还研究了电压的幅度和电极齿对的数量，以找到设备的最佳条件。据我们所知，这是首次在箔片实验室电气设备中演示交流电导流 (AC EOF)，以及微通道中垂直和水平 EOF 模式的探索。本研究提供了一种优化基于 EOF 的微混合器混合性能的方法。此外，该制造方法具有大规模生产低成本柔性电动微流体装置的潜力。
Efficient mixing of fluids in lab-on-a-chip devices is very important for many biomedical and biochemical applications. Lab-on-a-foil as a novel concept provides a method for fast prototyping or mass production of microfluidic devices based on thin and flexible films materials. In this article, electroosmosis micromixing is conducted in a lab-on-a-foil microfluidic device. With the electroosmotic flow (EOF), an efficient micromixing is realized inside a microchannel by tooth-shaped planar electrodes. The mixing performance is evaluated based on intensity measurement, and frequency sweeping is used to identify optimal performance. Furthermore, according to local intensity profiles, the EOF pattern is analyzed to provide a deep understanding on the influence of frequency and flow rate. The amplitude of voltage and the number of pairs of electrode tooth are also investigated to find the optimal conditions of the device. To the best of our knowledge, this is the first demonstration of the AC EOF in a lab-on-a-foil electric device and the exploration of EOF pattern vertically and horizontally in the microchannels. This study provides a method to optimize mixing performance in EOF-based micromixer. Furthermore, the fabrication method cast the potential for mass production of low-cost flexible electric microfluidic devices.