Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells.
Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells.
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Lungkine 是一种新型 CXC 趋化因子，由肺支气管上皮细胞特异性表达。
DOI：
10.4049/jimmunol.162.9.5490
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发表时间：
1999
影响因子：
4.4
通讯作者：
Albert Zlotnik
中科院分区：
文献类型：
--
作者：
D. Rossi;Stephen D. Hurst;Yuming Xu;Wei Wang;S. Menon;Robert L. Coffman;Albert Zlotnik
我们描述了一种新的小鼠CXC趋化因子，它选择性地在肺上皮细胞中表达，并在各种肺部炎症模型中上调。尽管这种趋化因子与其他ELR-CXC趋化因子聚簇，但基于序列同一性，它们中没有一个可以确信地被分配为其人类同源物。此外，这种趋化因子的高度限制的mRNA组织分布将其与所有先前描述的趋化因子区分开来：在对应于特定鼠细胞群和组织的70个cDNA文库中的任何一个中均未检测到肺因子。通过北方印迹和原位杂交，在肺中特异性检测到高水平的Lungkine mRNA，而在胎肺组织中检测到较低水平的Lungkine mRNA，这表明该趋化因子在肺发育过程中的潜在作用。此外，Lungkine蛋白分泌到气道空间中并诱导中性粒细胞的体外和体内迁移，表明其参与肺特异性中性粒细胞运输。使用荧光原位杂交，我们表明，Lungkine地图小鼠5号染色体。
We describe a novel mouse CXC chemokine that is selectively expressed in lung epithelial cells and up-regulated in various lung inflammation models. Although this chemokine clusters with other ELR-CXC chemokines, none of them can confidently be assigned to be its human homologue based on sequence identity. In addition, the highly restricted mRNA tissue distribution of this chemokine differentiates it from all previously described chemokines: Lungkine could not be detected in any of the 70 cDNA libraries analyzed corresponding to specific murine cell populations and tissues. High levels of Lungkine mRNA were specifically detected in the lung and at lower levels in fetal lung tissue by Northern blot and in situ hybridization, suggesting a potential role for this chemokine during lung development. Moreover, Lungkine protein is secreted into the airway spaces and induces the in vitro and in vivo migration of neutrophils, suggesting that it is involved in lung-specific neutrophil trafficking. Using fluorescent in situ hybridization, we show that Lungkine maps to mouse chromosome 5.
DOI：
10.1165/ajrcmb.14.3.8845182
发表时间：
1996-03-01
影响因子：
6.4
作者：
Bozic, CR;Gerard, NP;Gerard, C
通讯作者：
Gerard, C
DOI：
10.1164/ajrccm/148.3.713
发表时间：
1993-09-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
SUR, S;CROTTY, TB;GLEICH, GJ
通讯作者：
GLEICH, GJ