Modelling the visual response to an OUReP retinal prosthesis with photoelectric dye coupled to polyethylene film
Modelling the visual response to an OUReP retinal prosthesis with photoelectric dye coupled to polyethylene film
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DOI：
10.1088/1741-2552/abf892
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发表时间：
2021-04
影响因子：
4
通讯作者：
Koichiro Yamashita;P. Sundaram;Tetsuya Uchida;T. Matsuo;W. Wong
中科院分区：
文献类型：
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作者：
Koichiro Yamashita;P. Sundaram;Tetsuya Uchida;T. Matsuo;W. Wong
Objective.视网膜假体已经被开发出来，用于恢复患有视网膜色素变性等疾病的盲人的视力。Approach.通过将光电染料化学偶联到聚乙烯膜表面，开发了一种称为冈山大学型视网膜假体（OUReP）的新型视网膜假体。假肢的工作原理是在光的刺激下被动地产生电势。然而，OUReP如何刺激变性视网膜的神经生理机制尚不清楚。主要结果。在这里，我们探讨如何OUReP影响视网膜组织使用有限元模型来解决组织内的潜力和积极的霍奇金-赫胥黎模型的基础上，大鼠的视力来预测相应的视网膜双极反应。意义我们表明，OUReP可能能够引起在大多数环境条件下产生视觉所需的视网膜双极细胞的反应。
Objective. Retinal prostheses have been developed to restore vision in blind patients suffering from diseases like retinitis pigmentosa. Approach. A new type of retinal prosthesis called the Okayama University-type retinal prosthesis (OUReP) was developed by chemically coupling photoelectric dyes to a polyethylene film surface. The prosthesis works by passively generating an electric potential when stimulated by light. However, the neurophysiological mechanism of how OUReP stimulates the degenerated retina is unknown. Main results. Here, we explore how the OUReP affects retinal tissues using a finite element model to solve for the potential inside the tissue and an active Hodgkin–Huxley model based on rat vision to predict the corresponding retinal bipolar response. Significance. We show that the OUReP is likely capable of eliciting responses in retinal bipolar cells necessary to generate vision under most ambient conditions.