Childhood immuno-metabolic markers and risk of depression and psychosis in adulthood: A prospective birth cohort study.
Childhood immuno-metabolic markers and risk of depression and psychosis in adulthood: A prospective birth cohort study.
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儿童免疫代谢标志物与成年抑郁症和精神病的风险：一项前瞻性出生队列研究。
DOI：
10.1016/j.psyneuen.2022.105707
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发表时间：
2022
影响因子：
3.7
通讯作者：
Donnelly NA
中科院分区：
文献类型：
--
作者：
Donnelly NA
背景代谢和炎症性疾病通常与抑郁症和精神病同时发生，新的证据表明免疫代谢功能障碍是其病因。先前的研究报告了患有抑郁症和精神病的成年人的代谢功能障碍和炎症。然而，纵向研究测试协会的方向，不同尺寸的早期生活免疫代谢功能障碍对成人psychopathology.MethodsUsing数据从3258出生队列参与者，我们研究了纵向协会的三个代谢激素（瘦素，脂联素，胰岛素）在9岁的风险抑郁症和精神病谱结果在24岁。此外，使用九种免疫代谢生物标志物，（瘦素、脂联素、胰岛素、白细胞介素-6、C-反应蛋白、低密度脂蛋白、高密度脂蛋白、甘油三酯和BMI），我们构建了一个探索性双因素模型，显示了一个一般免疫代谢因素和三个特定因素（肥胖、炎症和胰岛素抵抗），结果儿童期瘦素与成人期抑郁发作相关（校正比值比（aOR）= 1.31; 95% CI，1.02-1.71）和阴性症状（aOR=1.15; 95% CI，1.07-1.24），但无阳性精神病性症状。一般免疫代谢因素与非典型抑郁症状（aOR=1.07; 95%CI，1.01-1.14）和精神病经历（aOR=1.21; 95%CI，1.02-1.44）相关。肥胖因素与阴性症状相关（aOR=1.07; 95%CI 1.02-1.12）。女性的点估计值往往更大，尽管95%的可信区间与男性重叠。在妇女中，炎症因子与抑郁发作（aOR=1.27; 95%CI，1.03-1.57）。ConclusionsWhile一般免疫代谢功能障碍在儿童期可能有助于风险的精神病和抑郁症状在成年期，儿童肥胖和炎症似乎特别与情感（抑郁和消极），但不是积极的精神病症状。
BackgroundMetabolic and inflammatory disorders commonly co-occur with depression and psychosis, with emerging evidence implicating immuno-metabolic dysfunction in their aetiology. Previous studies have reported metabolic dysfunction and inflammation in adults with depression and psychosis. However, longitudinal studies testing the direction of association, and the effects of different dimensions of early-life immuno-metabolic dysfunction on adult psychopathology are limited.MethodsUsing data from 3258 birth cohort participants we examined longitudinal associations of three metabolic hormones (leptin, adiponectin, insulin) at age 9 with risks for depression- and psychosis-spectrum outcomes at age 24. In addition, using nine immuno-metabolic biomarkers (leptin, adiponectin, insulin, interleukin-6, C-Reactive protein, low density lipoprotein, high density lipoprotein, triglycerides, and BMI), we constructed an exploratory bifactor model showing a general immuno-metabolic factor and three specific factors (adiposity, inflammation, and insulin resistance), which were also used as exposures.ResultsChildhood leptin was associated with adult depressive episode (adjusted odds ratio (aOR)= 1.31; 95% CI, 1.02–1.71) and negative symptoms (aOR=1.15; 95% CI, 1.07–1.24), but not positive psychotic symptoms. The general immuno-metabolic factor was associated with atypical depressive symptoms (aOR=1.07; 95% CI, 1.01–1.14) and psychotic experiences (aOR=1.21; 95% CI, 1.02–1.44). The adiposity factor was associated with negative symptoms (aOR=1.07; 95% CI 1.02–1.12). Point estimates tended to be larger in women, though 95% credible intervals overlapped with those for men. In women, the inflammatory factor was associated with depressive episodes (aOR=1.27; 95% CI, 1.03–1.57).ConclusionsWhile general immuno-metabolic dysfunction in childhood may contribute to risks for both psychotic and depressive symptoms in adulthood, childhood adiposity and inflammation appear to be particularly linked to affective (depressive and negative), but not positive psychotic symptoms.