NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores
NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores
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DOI：
10.1042/bst0340922
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发表时间：
2006-11-01
影响因子：
3.9
通讯作者：
Galione, A.
中科院分区：
文献类型：
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作者：
Galione, A.
NAADP（nicotinicacid-adenine dinucleotide phosphate）是一种新近发现的钙离子动员分子。首先在海胆卵中表征，它已被证明可以从来自不同生物体的广泛细胞中的细胞内储存中动员Ca 2+。它是一种非常有效的分子，最近的报告表明，其细胞水平的变化，以响应各种激动剂，确认其作为Ca 2+动员信使的作用。在许多情况下，NAADP似乎与其他Ca 2+动员信使，如IP 3（肌醇1，4，5-三磷酸）和cADP-核糖在塑造胞质Ca 2+信号。目前尚不清楚的是NAADP敏感的Ca 2+释放机制的分子性质及其亚细胞定位。本文综述了最近在海胆卵中所取得的进展，这表明NAADP激活了一种新的Ca 2+释放通道，不同于相对较好表征的IP 3和ryanodine受体。此外，在海胆卵中，NAADP敏感的商店似乎是独立的内质网，最有可能是一个酸性商店。这些研究结果也得到了类似的研究结果在哺乳动物细胞中，NAADP诱导的Ca 2+信号的统一模型。
NAADP (nicotinic acid-adenine dinucleotide phosphate) is a recently described Ca2+-mobilizing molecule. First characterized in the sea urchin egg, it has been shown to mobilize Ca2+ from intracellular stores in a wide range of cells from different organisms. It is a remarkably potent molecule, and recent reports show that its cellular levels change in response to a variety of agonists, confirming its role as a Ca2+-mobilizing messenger. In many cases, NAADP appears to interact with other Ca2+-mobilizing messengers such as IP3 (inositol 1,4,5-trisphosphate) and cADP-ribose in shaping cytosolic Ca2+ signals. What is not clear is the molecular nature of the NAADP-sensitive Ca2+ release mechanism and its subcellular localization. This review focuses on the recent progress made in sea urchin eggs, which indicates that NAADP activates a novel Ca2+ release channel distinct from the relatively well-characterized IP3 and ryanodine receptors. Furthermore, in the sea urchin egg, the NAADP-sensitive store appears to be separate from the endoplasmic reticulum and is most likely an acidic store. These findings have also been reinforced by similar findings in mammalian cells, and a unified model for NAADP-induced Ca2+ signalling is presented.