5α-Reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum
5α-Reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum
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DOI：
10.1248/bpb.29.392
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发表时间：
2006-02-01
影响因子：
2
通讯作者：
Kondo, R
中科院分区：
文献类型：
--
作者：
Liu, J;Kurashiki, K;Kondo, R
5 α-还原酶抑制活性引导的灵芝子实体乙醇提取物的分级分离 (LEYSS.:FR.) KARST。 （灵芝科）在日本称为灵芝或甘露，在中国称为灵芝，分离出两种活性化合物，即灵芝酸DM和5α-lanosta-7,9(11),24-三烯-15α,26-二羟基-3-酮，IC50分别为10.6μm和41.9μm。灵芝酸DM的侧链羧基对于引发抑制活性至关重要，因为其甲酯的活性要低得多。
5 alpha-Reductase inhibitory activity-guided fractionation of the EtOH extract of the fruiting body of Ganoderma lucidum (LEYSS.:FR.) KARST. (Ganodermataceae), which is called Reishi, or Mannentake in Japan and Lingzhi in China, led to the isolation of two active compounds which were ganoderic acid DM and 5 alpha-lanosta-7,9(11),24-triene-15 alpha,26-dihydroxy-3-one with an IC50 of 10.6 mu m and 41.9 mu m respectively. A carboxyl group of side chain of ganoderic acid DM is essential to elicit the inhibitory activity because of much less activity of its methyl ester.