Association between cystoid spaces on indocyanine green hyperfluorescence and optical coherence tomography after vitrectomy for diabetic macular oedema.
Association between cystoid spaces on indocyanine green hyperfluorescence and optical coherence tomography after vitrectomy for diabetic macular oedema.
复制标题
糖尿病黄斑水肿玻璃体切除术后吲哚菁绿超荧光囊样空间与光学相干断层扫描之间的关联。
作者：
Yoshitake S;Murakami T;Uji A;Ogino K;Horii T;Hata M;Arichika S;Nishijima K;Yoshimura N.
目的回顾分析糖尿病黄斑水肿(DMO)患者玻璃体切割术后残留吲哚青绿(ICG)荧光的特征及其与光谱域光学相干断层扫描(SD-OCT)的关系。方法对12例(13只眼)糖尿病黄斑水肿患者在玻璃体切割联合ICG辅助内界膜剥离治疗5d后，分别用HRA2和SpectralisOCT获得眼底近红外荧光和视网膜切片图像。分析SD-OCT图像上ICG强荧光特征与外丛状层(OPL)囊样间隙的关系。结果玻璃体切割术后5d，20次OCT径向扫描共显示390个ICG强荧光区域。黄斑旁或黄斑周围的ICG强荧光面积明显小于中心凹。黄斑旁和卵圆周的强荧光区多为不规则形，而中心凹38个强荧光区中有18个为圆形或椭圆形(P<；0.001)。在73个强荧光区域中，SD-OCT显示的囊样间隙明显多于OCT上未显示囊样间隙的区域(P<；0.001和P=0.002)。在OCT图像的123个囊状间隙中，44个没有ICG强荧光，OCT反射率较低，高反射灶比ICG高荧光的少(P<；0.001和P=0.020)。结论本研究结果为黄斑裂孔的ICG强荧光及其与OCT特征的关系提供了新的解释。
PurposeTo study retrospectively the characteristics of residual indocyanine green (ICG) fluorescence after ICG-assisted vitrectomy and the association with spectral-domain optical coherence tomography (SD-OCT) findings in diabetic macular oedema (DMO).MethodsThirteen consecutive eyes of 12 patients for whom fundus near-infrared fluorescence and 20 retinal sectional images were obtained using HRA2 and Spectralis OCT, respectively, 5 days after vitrectomy combined with ICG-assisted inner limiting membrane peeling for DMO. The relationship between the characteristics of the ICG hyperfluorescence and the cystoid spaces in the outer plexiform layer (OPL) on SD-OCT images was evaluated.ResultsA total of 390 well-demarcated areas of ICG hyperfluorescence were delineated on 20 radial OCT scans dissecting the fovea 5 days after vitrectomy. The areas of ICG hyperfluorescence in the parafovea or perifovea were significantly smaller than those at the fovea. Most areas of hyperfluorescence were irregularly shaped in the parafovea and perifovea, whereas 18 of 38 areas of hyperfluorescence were round or oval at the fovea (P< 0.001). SD-OCT delineated the cystoid spaces in the OPL in 73 areas of hyperfluorescence that were round or oval and accompanied by dark spots more frequently than that without cystoid spaces on OCT images (P< 0.001 and P= 0.002). Of the 123 cystoid spaces in the OPL on OCT images, 44 did not have ICG hyperfluorescence, had lower OCT reflectivity, and contained fewer hyperreflective foci than those with ICG hyperfluorescence (P< 0.001 and P= 0.020).ConclusionThe results provided novel interpretations of the ICG hyperfluorescence and its association with OCT characteristics of the cystoid spaces in DMO.