Ligand-free palladium catalyzed Ullmann biaryl synthesis: "household' reagents and mild reaction conditions
Ligand-free palladium catalyzed Ullmann biaryl synthesis: "household' reagents and mild reaction conditions
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DOI：
10.1039/c8gc03862g
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发表时间：
2019-03-07
期刊：
影响因子：
9.8
通讯作者：
Zhu, Chunyin
中科院分区：
文献类型：
--
作者：
Gong, Xinchi;Wu, Jie;Zhu, Chunyin
以水合肼为还原剂，室温下钯催化Ullmann联芳基合成反应。Pd（0Ac）（2）和水合肼的组合对于富电子和缺电子芳基碘以及杂芳基碘的偶联顺利地起作用，从而以良好至优异的产率产生宽范围的联芳基化合物。该反应仅需1mol%Pd（0Ac）（2），原位生成的钯纳米粒子是活性催化剂。
A palladium catalysed Ullmann biaryl synthesis has been developed using hydrazine hydrate as the reducing reagent at room temperature. The combination of Pd(OAc)(2) and hydrazine hydrate works smoothly for the coupling of both electron-rich and electron-deficient aryl iodides, as well as hetero-aryl iodides, leading to a wide range of biaryls in good to excellent yields. The reaction requires only 1 mol% Pd(OAc)(2) and the in situ generated palladium naoparticles are found to be active catalysts.