Towards an electroretinographic assay for studying colour vision in human observers
Towards an electroretinographic assay for studying colour vision in human observers
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DOI：
10.1007/s10633-016-9561-y
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发表时间：
2016-10-01
影响因子：
1.4
通讯作者：
Bhatt, Deepak
中科院分区：
文献类型：
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作者：
Kremers, Jan;Bhatt, Deepak
为确定异色刺激的视网膜电图（ERG）是否能检测和量化遗传性色觉缺陷，测量了红、绿色刺激的反相调制ERGs。红色和绿色刺激的总调制深度是恒定的。改变红色与绿色调制的比率，并且在两个时间频率：12和36 Hz下测量响应。受试者是13 protanopes，19 protanomalous三色，38 deuteranopes，16 deuteramorphous三色和22正常trichromats.The反应是在协议与以前的研究结果：他们是由一个矢量添加剂输入的L-和M-锥（因此是亮度敏感）在36 Hz。在12 Hz时，响应可以被建模为L-/M-加性响应（如由36 Hz ERG确定的）和L-/M-对手响应的矢量相加。从模型中，L-视锥细胞输入分数（36 Hz）和亮度输入分数（12 Hz）进行了估计。这五个群体表现出不同的特点。然而，在12 Hz的信噪比（SNR）并不总是令人满意的ERG异色刺激是潜在的有趣的确定的存在和类型的色觉缺陷，提供了一些措施，以改善12 Hz的SNR。
To determine whether electroretinograms (ERGs) to heterochromatic stimulation can detect and quantify hereditary colour vision deficiency.ERGs were measured to counterphase modulation of red and green stimuli. The total modulation depth of the red and green stimuli was constant. The ratio of red to green modulation was varied, and the responses were measured at two temporal frequencies: 12 and 36 Hz. Subjects were 13 protanopes, 19 protanomalous trichromats, 38 deuteranopes, 16 deuteranomalous trichromats and 22 normal trichromats.The responses are in agreement with previous findings: they were determined by a vector additive input of L- and M-cones (and thus is luminance sensitive) at 36 Hz. At 12 Hz, the responses can be modelled a vector addition of an L-/M-additive response (as determined by the 36 Hz ERGs) and an L-/M-opponent response. From the models, L-cone input fraction (36 Hz) and luminance input fraction (12 Hz) were estimated. The five groups showed different characteristics. However, the signal-to-noise ratio (SNR) at 12 Hz was not always satisfactory.The ERGs to heterochromatic stimuli are potentially interesting for determining the presence and the type of colour vision deficiencies, provided some measures are taken to improve the 12 Hz SNRs.