Polymerized Human Placenta Hemoglobin Given Before Ischemia Protects Rat Heart from Ischemia Reperfusion Injury
Polymerized Human Placenta Hemoglobin Given Before Ischemia Protects Rat Heart from Ischemia Reperfusion Injury
复制标题
缺血前给予聚合人胎盘血红蛋白可保护大鼠心脏免受缺血再灌注损伤
DOI：
10.3109/10731199.2011.611472
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发表时间：
2011-12-01
期刊：
影响因子：
--
通讯作者：
Yang, Chengmin
中科院分区：
文献类型：
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作者：
Li, Tao;Zhou, Ronghua;Yang, Chengmin
本研究旨在探讨缺血前给予多聚人胎盘血红蛋白（PolyPHb）对缺血/再灌注（I/R）损伤大鼠心功能的保护作用。将45只雄性SD大鼠随机分为假手术组、对照组和PolyPHb组，每组15只。大鼠心脏进行30分钟的缺血通过闭塞的左前降支，随后2小时的再灌注。与对照组相比，PolyPHb保留了心脏功能，减少了心肌肌钙蛋白-I的释放和组织病理学变化。因此，PolyPHb预处理对体内大鼠心脏提供了深刻的心脏保护作用。
This study was to investigate whether polymerized human placenta hemoglobin (PolyPHb) given before ischemia protects in vivo rat heart function against ischemia/reperfusion (I/R) injury. Forty-five male Sprague-Dawley rats were randomly divided (n = 15 per group) into a sham group, control group (pretreatment with Lactated Ringer's solution), or PolyPHb group (pretreatment with 0.1gHb/kg PolyPHb). Rat hearts were subjected to 30-min ischemia by occlusion of left anterior descending, followed by 2-hr reperfusion. As compared to the control group, PolyPHb preserved cardiac function and reduced cardiac troponin-I release and histopathological changes. Therefore, PolyPHb pretreatment provided a profound cardioprotective effect on the in vivo rat heart.