Abnormal fronto-limbic engagement in incarcerated stimulant users during moral processing.
Abnormal fronto-limbic engagement in incarcerated stimulant users during moral processing.
复制标题
被监禁的兴奋剂使用者在道德处理过程中额叶边缘的异常参与。
DOI：
10.1007/s00213-016-4344-4
复制
发表时间：
2016
影响因子：
3.4
通讯作者：
Kiehl,KentA
中科院分区：
文献类型：
--
作者：
Fede,SamanthaJ;Harenski,CarlaL;SchaichBorg,Jana;Sinnott-Armstrong,Walter;Rao,Vikram;Caldwell,BrendanM;Nyalakanti,PrashanthK;Koenigs,MichaelR;Decety,Jean;Calhoun,VinceD;Kiehl,KentA
使用兴奋剂是一个严重和普遍的问题，特别是在犯罪人口中。先前的研究发现，可卡因和甲基苯丙胺的使用与识别情绪和同情心的障碍有关。兴奋剂使用者的腹内侧前额叶皮层（vmPFC）、杏仁核、前扣带回（ACC）和后扣带回（PCC）的神经结构和功能也异常，这些区域与道德决策有关。然而，没有研究已经研究了神经相关的兴奋剂的使用和明确的道德加工在一个监禁population.ObjectivesHere，我们研究兴奋剂的使用如何影响sociomoral处理，可能有助于反社会行为。我们预测，vmPFC，杏仁核，PCC，ACC将显示异常的神经反应，在道德处理任务在监禁甲基苯丙胺和可卡因users.MethodsIncarcered成年男性（N= 211）进行了扫描与移动的MRI系统，同时完成道德决策任务。评估了终生药物使用情况。比较了使用者和非使用者在道德加工过程中的神经反应。持续时间的使用和神经功能之间的关系也examined.ResultsIncarcerated兴奋剂用户表现出较少的杏仁核参与比非用户在道德处理。兴奋剂使用的持续时间呈负相关，与活动在ACC和正相关的VMPFC反应在moral processing.ConclusionsThese结果表明，一个动态模式的额叶边缘系统的道德处理有关的兴奋剂使用赤字的中央动机和认知整合元素的生物道德过程理论。这增加了我们对药物使用如何与超高风险人群大脑中的道德处理相关的理解。
RationaleStimulant use is a significant and prevalent problem, particularly in criminal populations. Previous studies found that cocaine and methamphetamine use is related to impairment in identifying emotions and empathy. Stimulant users also have abnormal neural structure and function of the ventromedial prefrontal cortex (vmPFC), amygdala, and anterior (ACC) and posterior cingulate (PCC), regions implicated in moral decision-making. However, no research has studied the neural correlates of stimulant use and explicit moral processing in an incarcerated population.ObjectivesHere, we examine how stimulant use affects sociomoral processing that might contribute to antisocial behavior. We predicted that vmPFC, amygdala, PCC, and ACC would show abnormal neural response during a moral processing task in incarcerated methamphetamine and cocaine users.MethodsIncarcerated adult males (N= 211) were scanned with a mobile MRI system while completing a moral decision-making task. Lifetime drug use was assessed. Neural responses during moral processing were compared between users and non-users. The relationship between duration of use and neural function was also examined.ResultsIncarcerated stimulant users showed less amygdala engagement than non-users during moral processing. Duration of stimulant use was negatively associated with activity in ACC and positively associated with vmPFC response during moral processing.ConclusionsThese results suggest a dynamic pattern of fronto-limbic moral processing related to stimulant use with deficits in both central motive and cognitive integration elements of biological moral processes theory. This increases our understanding of how drug use relates to moral processing in the brain in an ultra-high-risk population.