Differing effects of epinephrine, norepinephrine, and vasopressin on survival in a canine model of septic shock.
Differing effects of epinephrine, norepinephrine, and vasopressin on survival in a canine model of septic shock.
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肾上腺素、去甲肾上腺素和加压素对感染性休克犬模型生存的不同影响。
DOI：
10.1152/ajpheart.00450.2004
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Solomon,StevenB
中科院分区：
文献类型：
--
作者：
Minneci,PeterC;Deans,KatherineJ;Banks,StevenM;Costello,Renee;Csako,Gyorgy;Eichacker,PeterQ;Danner,RobertL;Natanson,Charles;Solomon,StevenB
During sepsis, limited data on the survival effects of vasopressors are available to guide therapy. Therefore, we compared the effects of three vasopressors on survival in a canine septic shock model. Seventy-eight awake dogs infected with differing doses of intraperitonealEscherichia colito produce increasing mortality were randomized to receive epinephrine (0.2, 0.8, or 2.0 μg·kg−1·min−1), norepinephrine (0.2, 1.0, or 2.0 μg·kg−1·min−1), vasopressin (0.01 or 0.04 U/min), or placebo in addition to antibiotics and fluids. Serial hemodynamic and biochemical variables were measured. Increasing doses of bacteria caused progressively greater decreases in survival (P< 0.06), mean arterial pressure (MAP) (P< 0.05), cardiac index (CI) (P< 0.02), and ejection fraction (EF) (P= 0.02). The effects of epinephrine on survival were significantly different from those of norepinephrine and vasopressin (P= 0.03). Epinephrine had a harmful effect on survival that was significantly related to drug dose (P= 0.02) but not bacterial dose. Norepinephrine and vasopressin had beneficial effects on survival that were similar at all drug and bacteria doses. Compared with concurrent infected controls, epinephrine caused greater decreases in CI, EF, and pH, and greater increases in systemic vascular resistance and serum creatinine than norepinephrine and vasopressin. These epinephrine-induced changes were significantly related to the dose of epinephrine administered. In this study, the effects of vasopressors were independent of severity of infection but dependent on the type and dose of vasopressor used. Epinephrine adversely affected organ function, systemic perfusion, and survival compared with norepinephrine and vasopressin. In the ranges studied, norepinephrine and vasopressin have more favorable risk-benefit profiles than epinephrine during sepsis.
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DOI：
--
发表时间：
1971
期刊：
Surgical forum
影响因子：
--
作者：
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1.3
作者：
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DOI：
10.1097/00005373-199910000-00014
发表时间：
1999-10-01
影响因子：
--
作者：
Malay, MB;Ashton, RC;Townsend, RN
通讯作者：
Townsend, RN
影响因子：
38.9
作者：
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影响因子：
8.8
作者：
Bradley D. Freeman;Fabrice Zeni;S. Banks;P. Eichacker;John Bacher;Edward P. Garvey;Joel V. Tuttle;Cynthia H. Jurgensen;C. Natanson;Robert L. Danner
通讯作者：
Robert L. Danner