Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis
Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis
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DOI：
10.1002/art.1780391108
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发表时间：
1996-11-01
影响因子：
--
通讯作者：
Zegers, BJM
中科院分区：
文献类型：
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作者：
Prakken, ABJ;vanEden, W;Zegers, BJM
目标。目的：探讨T淋巴细胞对人内源性HSP60的反应性在少关节幼年类风湿关节炎(JRA)发病过程中的调节作用。对15例新诊断的人类白细胞抗原B27阴性的少关节JRA患者的T细胞对HSP的反应性进行了前瞻性纵向研究，并与20例新诊断的多关节或系统性JRA患者的结果进行了比较。或由其他系统疾病或病毒感染引起的急性关节炎，以及9名健康对照组受试者。在86%(13/15)的少关节JRA患者中，在发病3个月内，外周血和/或滑液单个核细胞对HSP60有明显的T淋巴细胞增殖反应。风湿病对照组中仅有5%(1/20)的患者Hsp60阳性，所有少关节JRA患者均在12周内病情缓解，在此缓解期内采集8例患者的血样，与活动期患者相比，Hsp60反应明显降低，甚至为阴性，8例患者均为良好反应。结果表明，在少关节JRA病程的早期，T细胞对人HSP60的增殖反应明显，而且这些反应与疾病的活动性有关，T细胞对人HSP60的反应似乎与疾病的缓解有关。
Objective. To determine whether T lymphocyte reactivity to endogenous human hsp60 plays a regulatory role in the course of oligoarticular juvenile rheumatoid arthritis (JRA).Methods. A prospective, longitudinal study of T cell reactivity to HSP in 15 patients with newly diagnosed HLA-B27 negative oligoarticular JRA was performed, Results were compared with those in a group of 20 patients with newly diagnosed polyarticular or systemic JRA. or with acute arthritis caused by other systemic diseases or viral infections, as well as with those in a group of 9 healthy control subjects.Results. In 86% of the patients with oligoarticular JRA (13 of 15), significant T lymphocyte proliferative responses to hsp60 were found in peripheral blood mononuclear cells and/or synovial fluid mononuclear cells within 3 months after the onset of arthritis. Only 5% of the patients in the rheumatologic disease control group (1 of 20) showed such positivity, All patients with oligoarticular JRA and positive responses to human hsp60 developed a remission of their disease within 12 weeks, During this period of remission, blood samples were taken from 8 patients and showed significantly lower and even negative responses to hsp60, compared with active disease, when all 8 patients had good responses.Conclusion. The results show that significant proliferative responses to human hsp60 can be found early in the course of oligoarticular JRA, Furthermore, these responses correlate with disease activity in such a manner that T cell reactivity to human hsp60 seems to be associated with disease remission.