Epidemiology of candiduria and Candida urinary tract infections in inpatients and outpatients: results from a 10-year retrospective survey
Epidemiology of candiduria and Candida urinary tract infections in inpatients and outpatients: results from a 10-year retrospective survey
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DOI：
10.5173/ceju.2019.1909
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发表时间：
2019-01-01
影响因子：
1.2
通讯作者：
Burian, Katalin
中科院分区：
文献类型：
--
作者：
Gajdacs, Mario;Doczi, Ilona;Burian, Katalin
简介 尿液中存在念珠菌（念珠菌尿）是一种常见的临床发现，通常可能代表标本定植或污染，但是，它们可能是尿路感染 (UTI) 的病原体，或者是泌尿生殖系统潜在病理或播散性念珠菌血症的指标。白色念珠菌是该属中最常见的分离物种，然而，据报道非白色念珠菌属念珠菌属 (NACS) 的发生率有所增加，这可能是由于频繁接触氟康唑所致。 材料和方法 本研究的目的是回顾性评估和比较念珠菌属引起的念珠菌尿和尿路感染的患病率。在匈牙利一家主要临床中心的住院患者和门诊患者中进行了为期 10 年（2008-2017）的调查。 结果 门诊患者的阳性样本中检测到念珠菌的比例为 0.11-0.75%，而住院患者的这一数字明显更高，为 3.49-10.63%（p < 0.001）。总体而言，白色念珠菌是最常见的分离菌种（门诊患者中为 65.22%，住院患者中为 59.64%），然而，光滑念珠菌作为相关病原体的存在（约占 20-30%）也值得注意，因为存在相应的治疗后果。 结论 女性占主导地位（1.7-2.15 倍），高龄（约 70 岁）年）和念珠菌尿期间受影响患者的住院情况与文献中的发现一致。
Introduction The presence of Candida species in urine (candiduria) is a common clinical finding, which may frequently represent colonization or contamination of specimens, however, they may be etiological agents in urinary tract infections (UTIs) or be indicators of underlying pathology in the genitourinary system or disseminated candidaemia. C. albicans is the most frequently isolated species of the genus, however, an increase in the occurrence of non-albicans Candida species (NACS) has been reported, which may be attributable to frequent exposure to fluconazole.Material and methods The aim of this study was to retrospectively assess and compare the prevalence of candiduria and UTIs caused by Candida spp. among inpatients and outpatients at a major clinical center in Hungary, during a 10-year period (2008-2017).Results Candiduria was detected in 0.11-0.75% of positive samples from outpatients, while this number was significantly higher for inpatients, ranging between 3.49-10.63% (p < 0.001). Overall, C. albicans was the most frequently isolated species (65.22% in outpatients and 59.64% in inpatients), however, the presence of C. glabrata as a relevant etiologic agent (similar to 20-30%) is also noteworthy, because there are corresponding therapeutic consequences.Conclusions A pronounced female dominance (1.7-2.15-fold), advanced age (similar to 70 years) and hospitalization of affected patients during candiduria is in line with the findings in literature.