Transcranial direct current stimulation of the unaffected hemisphere in stroke patients
Transcranial direct current stimulation of the unaffected hemisphere in stroke patients
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DOI：
10.1097/01.wnr.0000177010.44602.5e
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发表时间：
2005-09-28
期刊：
影响因子：
1.7
通讯作者：
Pascual-Leone, A
中科院分区：
文献类型：
--
作者：
Fregni, F;Boggio, PS;Pascual-Leone, A
中风后功能的恢复取决于受影响和未受影响的大脑半球的神经网络活动的平衡。受影响半球的活动增加可以促进恢复，而未受影响半球的过度活动可能代表一种适应不良的策略。因此，我们研究了阴极经颅直流电刺激是否会降低未受影响半球的兴奋性，从而改善中风患者的运动表现。我们将这些结果与受影响半球的兴奋性增强阳极经颅直流电刺激和假经颅直流电刺激进行了比较。对未受影响的半球进行阴极刺激和对受影响的半球进行阳极刺激（但不是假经颅直流电刺激）都显著改善了运动表现。这些结果表明，适当的双半球脑结构的调制可以促进运动功能的恢复。
Recovery of function after a stroke is determined by a balance of activity in the neural network involving both the affected and the unaffected brain hemispheres. Increased activity in the affected hemisphere can promote recovery, while excessive activity in the unaffected hemisphere may represent a maladaptive strategy. We therefore investigated whether reduction of the excitability in the unaffected hemisphere by cathodal transcranial direct current stimulation could result in motor performance improvement in stroke patients. We compared these results with excitability-enhancing anodal transcranial direct current stimulation of the affected hemisphere and sham transcranial direct current stimulation. Both cathodal stimulation of the unaffected hemisphere and anodal stimulation of the affected hemisphere (but not sham transcranial direct current stimulation) improved motor performance significantly. These results suggest that the appropriate modulation of bihemispheric brain structures can promote motor function recovery.