Establishment and function of tissue-resident innate lymphoid cells in the skin.
Establishment and function of tissue-resident innate lymphoid cells in the skin.
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DOI：
10.1007/s13238-017-0388-4
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发表时间：
2017-07
期刊：
影响因子：
21.1
通讯作者：
Xiong N
中科院分区：
文献类型：
--
作者：
Yang J;Zhao L;Xu M;Xiong N
先天性淋巴样细胞（inate lymphoid cells，ILC）是新近发现的一类淋巴样免疫细胞。虽然它们可以在淋巴器官和非淋巴组织中发现，但ILC优先富集在屏障组织如皮肤、肠和肺中，在这些组织中它们可以在维持组织完整性和功能以及保护免受外来物质的攻击方面发挥重要作用。另一方面，ILC的激活失调可能导致组织炎性疾病。尽管最近在了解ILC在健康和疾病中的作用方面取得了进展，但对ILC在屏障组织中的特异性建立、活化和功能的调节机制仍然知之甚少。我们在此回顾了最新的了解组织特异性相关的ILC。我们将特别关注皮肤的常驻ILC，这是最外层的屏障组织，在保护免受各种外来有害物质的侵害以及维持热和水平衡方面至关重要。此外，我们将讨论尚待解决的未决问题。
Innate lymphoid cells (ILCs) are a newly classified family of immune cells of the lymphoid lineage. While they could be found in both lymphoid organs and non-lymphoid tissues, ILCs are preferentially enriched in barrier tissues such as the skin, intestine, and lung where they could play important roles in maintenance of tissue integrity and function and protection against assaults of foreign agents. On the other hand, dysregulated activation of ILCs could contribute to tissue inflammatory diseases. In spite of recent progress towards understanding roles of ILCs in the health and disease, mechanisms regulating specific establishment, activation, and function of ILCs in barrier tissues are still poorly understood. We herein review the up-to-date understanding of tissue-specific relevance of ILCs. Particularly we will focus on resident ILCs of the skin, the outmost barrier tissue critical in protection against various foreign hazardous agents and maintenance of thermal and water balance. In addition, we will discuss remaining outstanding questions yet to be addressed.