ABNORMAL-DEVELOPMENT OF PERIPHERAL LYMPHOID ORGANS IN MICE DEFICIENT IN LYMPHOTOXIN
ABNORMAL-DEVELOPMENT OF PERIPHERAL LYMPHOID ORGANS IN MICE DEFICIENT IN LYMPHOTOXIN
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DOI：
10.1126/science.8171322
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发表时间：
1994-04-29
期刊：
影响因子：
56.9
通讯作者：
CHAPLIN, DD
中科院分区：
文献类型：
--
作者：
DETOGNI, P;GOELLNER, J;CHAPLIN, DD
虽然胸腺发育正常，但通过胚胎干细胞基因靶向导致淋巴素（LT）缺乏的小鼠没有形态学上可检测到的淋巴结或Peyer's斑块。在脾脏的白色髓内，B细胞和T细胞的正常分离失败。脾和外周血中含有CD4(+)CD8（-）和CD4(-)CD8(+) T细胞的比例正常，两种T细胞亚群具有明显正常的溶解功能。免疫球蛋白M阳性淋巴细胞在脾脏和外周血中数量增加：这些数据表明LT在外周血淋巴器官的正常发育中起重要作用。
Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4(+)CD8(-) and CD4(-)CD8(+) T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood: These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.