The chemokine SDF-1 regulates blastema formation during zebrafish fin regeneration
The chemokine SDF-1 regulates blastema formation during zebrafish fin regeneration
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DOI：
10.1007/s00427-006-0066-7
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发表时间：
2006-10-01
影响因子：
2.4
通讯作者：
Vriz, Sophie
中科院分区：
文献类型：
--
作者：
Dufourcq, Pascale;Vriz, Sophie
在这项研究中提出的工作集中在胚泡形成在表型再生。我们描述了Sdf1a和Sdf1b(基质细胞衍生因子-1a和1b)及其两个受体Cxcr4a和Cxcr4b在斑马鱼鳍再生中的表达模式。我们证明了Sdf1a/Cxcr4a在翅片再生中起关键作用，更准确地说，在表皮细胞增殖中起关键作用，表皮细胞增殖是胚泡形成的重要过程。在哺乳动物中，单个CXCR4基因既参与趋化作用，又参与细胞的增殖和存活；在本研究中，我们讨论了两个CXCR4基因可能的功能分裂。
The work presented in this study focuses on blastema formation in epimorphic regeneration. We describe the expression pattern of Sdf1a and Sdf1b (the chemokines stromal-cell-derived factor-1a and 1b) and their two receptors Cxcr4a and Cxcr4b during zebrafish fin regeneration. We demonstrate that Sdf1a/Cxcr4a plays a critical role in fin regeneration and more precisely in epidermal cell proliferation, an important process for blastema formation. In mammals, a single cxcr4 gene is involved both in chemotaxis and cell proliferation and survival; we discuss in this study a possible functional division of the two cxcr4 zebrafish genes.