Participant retention practices in longitudinal clinical research studies with high retention rates.
Participant retention practices in longitudinal clinical research studies with high retention rates.
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DOI：
10.1186/s12874-017-0310-z
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发表时间：
2017-02-20
影响因子：
4
通讯作者：
Himmelfarb CD
中科院分区：
文献类型：
--
作者：
Abshire M;Dinglas VD;Cajita MI;Eakin MN;Needham DM;Himmelfarb CD
有必要提高纵向研究中的队列保留率。我们的目标是确定队列保留策略和实施方法中使用的高保留率的研究。从美国一所大型研究密集型大学的机构审查委员会数据库中查询了≥200名受试者、≥1年随访期间保留率≥80%的纵向研究;通过网络识别了其他研究。22项合格研究中有19项（86%）同意参与。通过深入的半结构化访谈，参与者提供保留策略的基础上确定的主题，从以前的文献综述。数据的综合由一个多学科小组完成。最常用的保留策略是：研究提醒，研究访问的特点，强调研究的好处，和联系/调度策略。研究团队运转良好，组织有序，坚持不懈。此外，团队还根据参与者的情况制定策略，经常调整和创新他们的方法。这些研究包括专业和持久的团队，并利用针对其队列和个体参与者的定制策略。研究的书面协议和出版的手稿往往没有反映出在研究期间采用和适应的各种策略。适当的保留策略的使用需要文化敏感性，需要更多的研究，以确定如何在全球范围内使用不同的策略。
There is a need for improving cohort retention in longitudinal studies. Our objective was to identify cohort retention strategies and implementation approaches used in studies with high retention rates. Longitudinal studies with ≥200 participants, ≥80% retention rates over ≥1 year of follow-up were queried from an Institutional Review Board database at a large research-intensive U.S. university; additional studies were identified through networking. Nineteen (86%) of 22 eligible studies agreed to participate. Through in-depth semi-structured interviews, participants provided retention strategies based on themes identified from previous literature reviews. Synthesis of data was completed by a multidisciplinary team. The most commonly used retention strategies were: study reminders, study visit characteristics, emphasizing study benefits, and contact/scheduling strategies. The research teams were well-functioning, organized, and persistent. Additionally, teams tailored their strategies to their participants, often adapting and innovating their approaches. These studies included specialized and persistent teams and utilized tailored strategies specific to their cohort and individual participants. Studies’ written protocols and published manuscripts often did not reflect the varied strategies employed and adapted through the duration of study. Appropriate retention strategy use requires cultural sensitivity and more research is needed to identify how strategy use varies globally.