Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature.
Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature.
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DOI：
10.1161/circresaha.108.191239
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发表时间：
2009-01-30
影响因子：
20.1
通讯作者：
Ornitz DM
中科院分区：
文献类型：
--
作者：
Lavine KJ;Ornitz DM
缺血性心脏病是心力衰竭的最常见原因，并且是全世界死亡的主要原因之一。用于治疗这种疾病的疗法旨在通过基于导管或手术的手段恢复严重狭窄或闭塞的冠状动脉的血流。虽然这些策略证明对许多患者有效，但大量个体在这些程序后未能改善。最近，已经提出了一种非侵入性的策略，专注于使用内源性生长因子，触发新冠状动脉的生长。利用发育中的心脏作为模型，几个研究小组已经确定了一些关键途径，这些途径不仅控制冠状动脉血管系统的发育，而且促进成人冠状动脉血管系统的生长。在这里，我们回顾了主要的形态学事件和信号级联介导的形成冠状动脉血管在胚胎中。我们进一步描述了许多相同的途径也调节成人冠状动脉血管的机制及其在缺血性心脏病治疗中的潜在用途。
Ischemic heart disease is the most common cause of heart failure and is among the leading causes of mortality worldwide. Therapies employed for the treatment of this disease aim to restore blood flow to severely narrowed or occluded coronary arteries by either catheter-based or surgical means. While these strategies prove efficacious for many patients, a substantial number of individuals fail to improve following these procedures. Recently, a non-invasive strategy has been proposed, focusing on the use of endogenous growth factors that trigger the growth of new coronary arteries. Using the developing heart as a model, several groups have identified some of the key pathways that not only govern the development of the coronary vascular system, but also promote the growth of the adult coronary vasculature. Here, we review the major morphological events and signaling cascades that mediate the formation of the coronary vasculature in the embryo. We further describe the mechanism by which many of these same pathways also regulate the adult coronary vasculature and their potential use in the treatment of ischemic heart disease.