Attenuated pain responses in mice lacking CaV3.2 T-type channels
Attenuated pain responses in mice lacking CaV3.2 T-type channels
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DOI：
10.1111/j.1601-183x.2006.00268.x
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发表时间：
2007-07-01
影响因子：
2.5
通讯作者：
Shin, H.-S.
中科院分区：
文献类型：
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作者：
Choi, S.;Na, H. S.;Shin, H.-S.
虽然T型钙通道与伤害性感受有关，但具体亚型的功能尚未很好地确定。在此，我们比较了缺乏Ca(V)3.2亚型T型钙通道(Ca(V)3.2(-/-))的小鼠和野生型小鼠在不同疼痛行为模型中的疼痛敏感性，以探讨Ca(V)3.2在体内处理伤害性刺激中的作用。在急性机械、热和化学疼痛测试中，与野生型小鼠相比，Ca(V)3.2(-/-)小鼠的疼痛反应减弱。CA(V)3.2(-/-)小鼠对紧张性伤害性刺激也表现出减轻的疼痛反应，如腹膜内注射刺激剂和皮内注射福尔马林。然而，在脊神经结扎诱导的神经病理性疼痛中，Ca(V)3.2(-/-)小鼠的行为反应与野生型小鼠没有区别。目前的研究表明，无论伤害性信号的形式、持续时间或受影响的组织类型如何，T-型钙离子通道的Ca(V)3.2亚型在外周处理伤害性信号中都是重要的。
Although T-type Ca2+ channels are implicated in nociception, the function of specific subtypes has not been well defined. Here, we compared pain susceptibility in mice lacking Ca(V)3.2 subtype of T-type Ca2+ channels (Ca(V)3.2(-/-)) with wild-type littermates in various behavioral models of pain to explore the roles of Ca(V)3.2 in the processing of noxious stimuli in vivo. In acute mechanical, thermal and chemical pain tests, Ca(V)3.2(-/-) mice showed decreased pain responses compared to wild-type mice. Ca(V)3.2(-/-) mice also displayed attenuated pain responses to tonic noxious stimuli such as intraperitoneal injections of irritant agents and intradermal injections of formalin. In spinal nerve ligation-induced neuropathic pain, however, behavioral responses of Ca(V)3.2(-/-) mice were not different from those of wild-type mice. The present study reveals that the Ca(V)3.2 subtype of T-type Ca2+ channels are important in the peripheral processing of noxious signals, regardless of modality, duration or affected tissue type.