The teflon gene is required for maintenance of autosomal homolog pairing at meiosis I in male Drosophila melanogaster.
The teflon gene is required for maintenance of autosomal homolog pairing at meiosis I in male Drosophila melanogaster.
复制标题
特氟隆基因是雄性果蝇减数分裂 I 时维持常染色体同源配对所必需的。
DOI：
10.1093/genetics/157.1.273
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发表时间：
2001
期刊：
影响因子：
3.3
通讯作者：
BriscoeJr,A
中科院分区：
文献类型：
--
作者：
Tomkiel,JE;Wakimoto,BT;BriscoeJr,A
In recombination-proficient organisms, chiasmata appear to mediate associations between homologs at metaphase of meiosis I. It is less clear how homolog associations are maintained in organisms that lack recombination, such as male Drosophila. In lieu of chiasmata and synaptonemal complexes, there must be molecules that balance poleward forces exerted across homologous centromeres. Here we describe the genetic and cytological characterization of four EMS-induced mutations inteflon(tef), a gene involved in this process inDrosophila melanogaster.All four alleles are male specific and cause meiosis I-specific nondisjunction of the autosomes. They do not measurably perturb sex chromosome segregation, suggesting that there are differences in the genetic control of autosome and sex chromosome segregation in males. Meiotic transmission of univalent chromosomes is unaffected intefmutants, implicating the tef product in a pairing-dependent process. The segregation of translocations between sex chromosomes and autosomes is altered intefmutants in a manner that supports this hypothesis. Consistent with these genetic observations, cytological examination of meiotic chromosomes suggests a role oftefin regulating or mediating pairing of autosomal bivalents at meiosis I. We discuss implications of this finding in regard to the evolution of heteromorphic sex chromosomes and the mechanisms that ensure chromosome disjunction in the absence of recombination.
