Opposing roles of nucleus accumbens core and shell dopamine in the modulation of limbic information processing.
Opposing roles of nucleus accumbens core and shell dopamine in the modulation of limbic information processing.
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DOI：
10.1523/jneurosci.6588-10.2011
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发表时间：
2011-04-20
期刊：
影响因子：
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通讯作者：
Hayen A
中科院分区：
文献类型：
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作者：
Ito R;Hayen A
多巴胺能神经支配的丘脑核（NAc）涉及的选择和整合的动机相关的皮质边缘系统的信息，管理行为输出。然而，它是未知的，如果多巴胺能神经支配的两个解剖学上不同的亚区的NAC，核心和外壳，有不同的作用，在这个门控过程中，多巴胺能机制是否是重要的，在调节平衡边缘系统控制食欲行为的学习点。先前已经表明，反复全身预处理安非他明破坏了竞争性边缘控制食欲行为的小鼠的调节，我们在此检查的影响，重复预训练内NAc壳或核心微量输注的d-安非他明，一般多巴胺（DA）受体拮抗剂顺式氟噻吨（FLU），或车辆解决方案（盐水）后，同时获得条件提示和位置偏好任务大鼠。重复注入安非他明到NAc壳和核心有相反的效果收购条件性位置偏爱显着增强，和衰减的位置条件分别依赖于海马。相比之下，直接注入氟噻吨到NAc壳衰减的位置调节，而NAc核心氟噻吨输液不仅衰减线索条件，但也增强了条件性位置偏爱。这些研究结果牵连的NAc壳DA是必要的，使大脑皮层依赖的空间信息获得控制食欲学习，和NAc核心DA是重要的，让基底外侧杏仁核依赖的信息获得控制食欲学习。有人进一步提出，NAc核心DA可能是至关重要的调节边缘系统的信息流通过NAc壳。
The dopaminergic innervation of the nucleus accumbens (NAc) is implicated in the selection and integration of motivationally relevant cortico-limbic information that governs behavioral output. However, it is unknown if the dopaminergic innervations of two anatomically distinct subregions of the NAc, core and shell, have differential roles in this gating process, and whether dopaminergic mechanisms are important in regulating the balance of limbic control over appetitive behavior at the point of learning. Having previously shown that repeated systemic pre-treatment with amphetamine disrupts the regulation of competing limbic control over appetitive behavior in mice, we hereby examined the effects of repeated pre-training intra-NAc shell or core microinfusions of d-amphetamine, general dopamine (DA) receptor antagonist cis-flupenthixol (FLU), or vehicle solution (saline) upon a simultaneously acquired conditioned cue and place preference task in rats. Repeated infusions of amphetamine into the NAc shell and core had opposite effects on the acquisition of conditioned place preference by significantly enhancing, and attenuating hippocampal-dependent place conditioning respectively. In contrast, direct infusions of flupenthixol into the NAc shell attenuated place conditioning, while NAc core flupenthixol infusions not only attenuated cue conditioning, but also enhanced conditioned place preference. These findings implicate the NAc shell DA as being necessary for enabling hippocampal-dependent spatial information to gain control over appetitive learning, and the NAc core DA as being important for allowing basolateral amygdala-dependent information to gain control over appetitive learning. It is further proposed that NAc core DA may be critical in regulating limbic information flow through the NAc shell.