Duplication events and the evolution of segmental identity
Duplication events and the evolution of segmental identity
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DOI：
10.1111/j.1525-142x.2005.05059.x
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发表时间：
2005-11-01
影响因子：
2.9
通讯作者：
Prince, VE
中科院分区：
文献类型：
--
作者：
Hurley, I;Hale, ME;Prince, VE
基因、基因组或形态结构（或它们的某些组合）的复制一直被认为促进了进化变化。在这里，我们将重点研究硬骨鱼，以考虑这三种不同类型的复制事件在进化潜力中的概念相似性。我们回顾了最近证实在鳍鱼谱系中发生的全基因组复制事件的数据，并讨论了这一事件是否可能助长了硬骨鱼的辐射。然后，我们从理论和实验的角度考虑个体复制基因的命运，重点研究硬骨鱼Hox基因及其在分割后脑模式中的功能。最后，我们考虑形态结构的重复，再次借鉴我们对后脑的实验研究，这些研究表明，实验诱导的重复神经元可以产生功能冗余的神经回路。我们假设，复制材料的可用性，独立于其性质，可以导致功能冗余，这反过来又使进化变化。
Duplication of genes, genomes, or morphological structures (or some combination of these) has long been thought to facilitate evolutionary change. Here we focus on studies of the teleost fishes to consider the conceptual similarities in the evolutionary potential of these three different kinds of duplication events. We review recent data that have confirmed the occurrence of a whole-genome duplication event in the ray-finned fish lineage, and discuss whether this event may have fuelled the radiation of teleost fishes. We then consider the fates of individual duplicated genes, from both a theoretical and an experimental viewpoint, focusing on our studies of teleost Hox genes and their functions in patterning the segmented hindbrain. Finally, we consider the duplication of morphological structures, once again drawing on our experimental studies of the hindbrain, which have revealed that experimentally induced duplicated neurons can produce functionally redundant neural circuits. We posit that the availability of duplicated material, independent of its nature, can lead to functional redundancy, which in turn enables evolutionary change.