Synthetic Peptides: A User's Guide
Synthetic Peptides: A User's Guide
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合成肽：用户指南
DOI：
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发表时间：
2002
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影响因子：
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通讯作者：
G. A. Grant
中科院分区：
文献类型：
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作者：
G. A. Grant
1. 概述合成多肽：21世纪开始参考文献2。肽设计注意事项蛋白质与氨基酸化学蛋白质结构序列分析在建模与设计中的应用组合肽库的设计与使用肽设计的其他方面固相多肽合成的原理和实践固相策略概述保护方案聚合物支持物附着于支持物多肽键形成固相合成监测自动化切割翻译后修饰和非自然结构辅助问题摘要缩写确认参考文献合成产物的评价一般考虑纯化共价结构的详细表征合成肽的储存和处理多少才足够合成多肽的应用介绍结构/功能研究系统修饰多肽作为酶抑制剂和治疗剂的应用受体研究——多肽在结构-活性关系研究中的应用概述多肽在受体亲和标记中的应用合成肽的抗原性和免疫原性应用反义肽摘要和未来展望缩略语列表致谢参考文献索引
1. OVERVIEW Synthetic Peptides: Beginning the Twenty-first Century References 2. PEPTIDE DESIGN CONSIDERATIONS Protein and Amino Acid Chemistry Protein Structure Application of Sequence Analysis to Modeling and Design Design and Use of Combinational Peptide Libraries Other Aspects of Peptide Design Summary References 3. PRINCIPLES AND PRACTICE OF SOLID-PHASE PEPTIDE SYNTHESIS Overview of Solid-Phase Strategy Protection Schemes Polymeric Support Attachment to Support Formation of Peptide Bond Monitoring Automation of Solid-Phase Synthesis Cleavage Post-Translational Modifications and Unnatural Structures Auxiliary Issues Summary Abbreviations Acknowledgments References 4. EVALUATION OF THE SYNTHETIC PRODUCT General Considerations Purification Detailed Characterization of Covalent Structure Storage and Handling of Synthetic Peptides How Much Is Enough Acknowledgments References 5. APPLICATIONS OF SYNTHETIC PEPTIDES Introduction Structure/Function Studies Systematic Modifications Use of Peptides as Enzymatic Inhibitors and Therapeutic Agents Receptor Studies - A Brief Overview of the Use of Peptides for Studies of Structure-Activity Relationships The Use of Peptides for Affinity Labeling of Receptors 6. ANTIGENIC AND IMMUNOGENIC USES OF SYNTHETIC PEPTIDES Antisense Peptides Summary and Future Perspectives List of Abbreviations Acknowledgements References Index