Epigenetic mechanisms and gastrointestinal development.
Epigenetic mechanisms and gastrointestinal development.
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DOI：
10.1016/j.jpeds.2006.06.064
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发表时间：
2006-11
期刊：
影响因子：
--
通讯作者：
R. Waterland
中科院分区：
文献类型：
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作者：
R. Waterland
本文综述了婴儿期营养影响肠道发育表观遗传学，导致胃肠（GI）结构和功能代谢印记的假说。综述了表观遗传基因调控的基本原理，重点是DNA甲基化的表观遗传机制。最近的数据表明，在产前和产后早期发育的关键时期，短暂的营养和其他刺激可以影响基因特异性DNA甲基化的建立或发育成熟，从而诱导基因表达的永久性变化。虽然表观遗传过程显然参与了哺乳动物出生后胃肠道的发展，我们目前对这些机制知之甚少。本文综述了表观遗传基因调控在胃肠道发育和病理中的重要作用，并对今后的研究提出了建议。
This review considers the hypothesis that nutrition during infancy affects developmental epigenetics in the gut, causing metabolic imprinting of gastrointestinal (GI) structure and function. Fundamentals of epigenetic gene regulation are reviewed, with an emphasis on the epigenetic mechanism of DNA methylation. Recent data indicate that transient nutritional and other stimuli during critical periods of prenatal and early postnatal development can affect the establishment or developmental maturation of gene-specific DNA methylation, thereby inducing permanent changes in gene expression. Although epigenetic processes are clearly involved in postnatal mammalian GI development, we currently know very little about these mechanisms. Data indicating that epigenetic gene regulation plays an important role in GI development and pathology are reviewed, and suggestions for future research in this area are offered.