Age at job initiation and risk of coronary heart disease: findings from the UK biobank cohort study.
Age at job initiation and risk of coronary heart disease: findings from the UK biobank cohort study.
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DOI：
10.1186/s12889-023-17034-3
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发表时间：
2023-10-30
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
过早开始工作与冠心病（CHD）的各种危险因素有关，例如轮班工作和高强度的工作压力。然而，过早开始工作与冠心病风险之间的关系在很大程度上仍不清楚。我们研究了工作开始年龄与冠心病风险之间的关系。英国生物银行的参与者年龄在38至70岁之间，没有心血管疾病，他们提供了工作开始时的年龄数据。主要终点为冠心病，通过医院和死亡记录确定。采用多变量Cox回归计算入职年龄与冠心病相关性的风险比（hr）和95%置信区间（CIs）。在501971名参与者中，114418名符合条件的参与者被纳入最终分析。开始工作的平均年龄为19.0岁。在平均12.6年的随访期间，发生了6130例（5.4%）首次冠心病事件。我们观察到，开始工作的年龄与冠心病呈负相关（HR 0.98, 95% CI 0.97-0.99），并且这种关联可能呈j型。与≥22岁组相比，< 17岁、17- 18岁和19 - 21岁年龄组的hr分别为1.29 （95%CI 1.18-1.41）、1.12 （95%CI 1.03-1.22）和1.05 （95%CI 0.97-1.14）。入职年龄与冠心病发病相关，与社会经济地位无关。在19岁之前开始工作的参与者在成年后患冠心病的风险更高。在线版本包含补充材料，可在10.1186/s12889-023-17034-3获得。
Commencing work at an early age has been linked to various risk factors for coronary heart disease (CHD), such as shift work and intensive job strain. However, the relationship between starting work too early and CHD risk remains largely unclear. We examined the association between age at job initiation and the risk of CHD. UK Biobank participants aged 38 to 70 years without cardiovascular disease who provided data on their age at job initiation were included. The primary outcome was CHD, which was ascertained using hospital and death records. The hazard ratios (HRs) and 95% confidence interval (CIs) for the association between age at job initiation and CHD were calculated using multivariable Cox regression. Of the 501,971 participants, 114,418 eligible participants were included in the final analysis. The median age at job initiation was 19.0 years. During the mean follow-up of 12.6 years, 6,130 (5.4%) first CHD events occurred. We observed that age at job initiation was inversely associated with CHD (HR 0.98, 95% CI 0.97–0.99), and the association was potentially J-shaped. The HRs for the < 17-year, 17–18-year, and 19–21-year age groups were 1.29 (95%CI 1.18–1.41), 1.12 (95% CI 1.03–1.22) and 1.05 (95% CI 0.97–1.14), respectively, compared with those of the ≥ 22-year group. Age at job initiation was associated with incident CHD, which was independent of socioeconomic status. Participants who commenced employment before the age of 19 years exhibited a higher risk of developing CHD later in adulthood. The online version contains supplementary material available at 10.1186/s12889-023-17034-3.
影响因子：
5
作者：
Marteleto LJ;Dondero M;Van Hook J;Gama LCD;Donnelly R
通讯作者：
Donnelly R