THE INTERPLAY OF GENETIC AND ENVIRONMENTAL INFLUENCES ON PREFRONTAL FUNCTION AND SELF-REGULATION OF IMPULSIVITY
THE INTERPLAY OF GENETIC AND ENVIRONMENTAL INFLUENCES ON PREFRONTAL FUNCTION AND SELF-REGULATION OF IMPULSIVITY
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DOI：
10.2117/psysoc.2011.241
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发表时间：
2011-12-01
期刊：
影响因子：
0.5
通讯作者：
Nomura, Michio
中科院分区：
文献类型：
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作者：
Nomura, Michio
通过执行资源的成熟来自我调节冲动，有利于我们的幸福。行为学、神经影像学和药理学研究的综述似乎提供了冲动性自我调节、前额叶皮层活动和多巴胺能神经传递之间关系的证据。虽然存在广泛的遗传、发育和社会因素，但其中许多信息，特别是它们的相互作用机制，仍有待澄清。因此，在这篇文章中，我首先回顾了自我调节过程的大脑功能，然后提供了一个更新的最新研究结果，关于多巴胺能神经传递。接下来，通过整合行为遗传学的研究结果，研究基因多态性和冲动之间的关联，我讨论了基因多态性的风险等位基因的光明面。最后，我认为遗传和环境双向研究的未来方向。
Self-regulation of impulsivity via maturation of the executive resources benefits our well-being. The review of behavioral, neuroimaging, and pharmacological studies appears to provide evidence of a relationship between the self-regulation of impulsivity, activity of the prefrontal cortex, and serotonergic neurotransmission. Although a wide range of genetic, developmental, and social factors exists, much of this information, their interactive mechanisms in particular, remains to be clarified. Thus, in the present article, I first review the brain functions that underlie self-regulative processes and then provide an update on recent findings regarding serotonergic neurotransmission. Next, by integrating findings from behavioral genetics that examine the association between gene polymorphism and impulsivity, I discuss the bright sides of the risk allele of gene polymorphism. Finally, I argue the future direction of genetic and environmental bidirectional studies.