Mitochondria on guard: role of mitochondrial fusion and fission in the regulation of apoptosis.
Mitochondria on guard: role of mitochondrial fusion and fission in the regulation of apoptosis.
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DOI：
10.1007/978-1-4419-6706-0_8
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发表时间：
2010
影响因子：
--
通讯作者：
M. Karbowski
中科院分区：
文献类型：
--
作者：
M. Karbowski
线粒体是高度动态的细胞器，其不断改变形状和结构以响应细胞的不同刺激和代谢需求。细胞中的线粒体结构主要受融合和分裂周期的调节。这两个过程受到严格的调节，在生理条件下，线粒体融合被裂变均匀地抵消。在细胞凋亡期间，线粒体经历广泛的片段化，这先于半胱天冬酶活化，而线粒体分裂机制的抑制阻断或延迟细胞死亡。异常的线粒体融合和分裂也是疾病发展的重要机制，在本章中，我们将简要讨论哺乳动物细胞中线粒体融合和分裂的机制，可能参与这些过程的线粒体形态发生蛋白以及这些过程在细胞活力中的作用。接下来将回顾最近的工作，将线粒体形态发生蛋白与凋亡中线粒体步骤的进展联系起来，以及刺激性的发现，这些发现表明某些与凋亡调控相关的蛋白也可以参与健康细胞中线粒体融合和裂变的调控。
Mitochondria are highly dynamic organelles that constantly change shape and structure in response to different stimuli and metabolic demands of the cell. Mitochondrial structure in the cell is predominantly regulated by cycles of fusion and fission. These two processes are tightly regulated and under physiological conditions, mitochondrial fusion is evenly counterbalanced by fission. During apoptosis, mitochondria undergo extensive fragmentation, which precedes caspase activation, whereas inhibition of the mitochondrial fission machinery blocks or delays cell death. Aberrant mitochondrial fusion and fission have also emerged as important mechanisms in the development of disease.In this chapter we will briefly discuss mechanisms of mitochondrial fusion and fission in mammalian cells, the mitochondrial morphogenesis proteins that may be involved in these processes and role of these processes in cell viability. This will be followed by a review of recent work connecting mitochondrial morphogenesis proteins with the progression of the mitochondrial steps in apoptosis, as well as stimulating findings showing that certain proteins associated with apoptosis regulation can also participate in the regulation of mitochondrial fusion and fission in healthy cells.