Local interactions select for lower pathogen infectivity
Local interactions select for lower pathogen infectivity
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DOI：
10.1126/science.1137126
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发表时间：
2007-03-02
期刊：
影响因子：
56.9
通讯作者：
Mealor, Michael
中科院分区：
文献类型：
--
作者：
Boots, Michael;Mealor, Michael
理论表明，目前连通性的快速增加以及人类、农业和野生动物种群结构的相应变化可能会选择具有更高传染性的寄生虫菌株。我们通过在一个模型宿主/病原体系统中通过改变环境的粘度来实验改变单个宿主的移动速率，从而对这一空间理论进行了测试。在我们的微进化选择实验中，正如理论预测的那样，在最粘性的种群中，病毒的传染性降低了。因此，我们为种群结构影响感染性生物进化的理论提供了经验支持。
Theory suggests that the current rapid increase in connectivity and consequential changes in the structure of human, agricultural, and wildlife populations may select for parasite strains with higher infectivity. We carried out a test of this spatial theory by experimentally altering individual host movement rates in a model host/pathogen system by altering the viscosity of their environment. In our microevolutionary selection experiments, the infectivity of the virus was, as predicted by the theory, reduced in the most viscous populations. We therefore provide empirical support for the theory that population structure affects the evolution of infectious organisms.