Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging
Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging
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DOI：
10.1176/appi.ajp.157.12.1994
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发表时间：
2000-12-01
影响因子：
17.7
通讯作者：
Hollander, E
中科院分区：
文献类型：
--
作者：
Haznedar, MM;Buchsbaum, MS;Hollander, E
目的：在自闭症的尸检研究中报告了前扣带皮层、海马、下托、内嗅皮层、杏仁核、乳头体和隔膜的细胞结构变化。此前，作者发现7名自闭症患者的扣带回体积较小，代谢降低。在这项研究中，他们测量了杏仁核，海马和扣带回的体积和葡萄糖代谢的扩展组的17例自闭症谱系障碍（自闭症[N=10]或Alfreger的障碍[N=7]）和17个年龄和性别匹配的健康志愿者。杏仁核，海马，扣带回概述了磁共振成像扫描，体积的结构被应用到匹配的coregistered正电子发射断层扫描，和三维显着性概率mapping performed.Results：显着的代谢减少在前和后扣带回的自闭症谱系障碍的患者可视化。经方差分析证实，Bogger和自闭症患者的前扣带回和后扣带回葡萄糖代谢均相对低下;三维显著性概率图也发现了区域差异。在杏仁核或海马体的代谢或体积方面没有发现组间差异。然而，自闭症谱系障碍患者的右前扣带回的体积减少，特别是在Brodmann区24 '。结论：与年龄和性别匹配的健康志愿者相比，自闭症谱系障碍患者的前扣带回和后扣带回的代谢显着降低。
Objective: Cytoarchitectonic changes in the anterior cingulate cortex, hippocampus, subiculum, entorhinal cortex, amygdala, mammillary bodies, and septum were reported in a postmortem study of autism. Previously, the authors found smaller cingulate volume and decreased metabolism of the cingulate in seven autistic patients. In this study, they measured the volume and glucose metabolism of the amygdala, hippocampus, and cingulate gyrus in an expanded group of 17 patients with autism spectrum disorders (autism [N=10] or Asperger's disorder [N=7]) and 17 age- and sex-matched healthy volunteers.Method: Subjects performed a serial verbal learning test during F-18-deoxyglucose uptake. The amygdala, hippocampus, and cingulate gyrus were outlined on magnetic resonance imaging scans, volumes of the structures were applied to matching coregistered positron emission tomography scans, and three-dimensional significance probability mapping was performed.Results: Significant metabolic reductions in both the anterior and posterior cingulate gyri were visualized in the patients with autism spectrum disorders. Both Asperger's and autism patients had relative glucose hypometabolism in the anterior and posterior cingulate as confirmed by analysis of variance; regional differences were also found with three-dimensional significance probability mapping. No group differences were found in either the metabolism or the volume of the amygdala or the hippocampus. However, patients with autism spectrum disorders showed reduced volume of the right anterior cingulate gyrus, specifically in Brodmann's area 24'.Conclusions: Compared with age- and sex-matched healthy volunteers, patients with autism spectrum disorders showed significantly decreased metabolism in both the anterior and posterior cingulate gyri.