Renal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System
Renal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System
复制标题
DOI：
10.1016/j.jacc.2018.08.2186
复制
发表时间：
2018-11-27
影响因子：
24
通讯作者：
Goodchild, Traci T.
中科院分区：
文献类型：
--
作者：
Sharp, Thomas E., III;Polhemus, David J.;Goodchild, Traci T.
背景技术以前，我们已经表明，射频（RF）肾去神经（RDN）在急性心肌梗死（MI）大鼠模型中减少心肌梗死面积，并在MI后心力衰竭的情况下改善左心室（LV）功能和血管反应性。方法用球囊闭塞尤卡坦小型猪冠状动脉左前降支75 min，建立心肌梗死模型，再灌注（R）18周。在MI/R前和MI/R后通过经胸超声心动图评估心功能，每3周一次，共18周。HFrEF按LV射血分数分类
BACKGROUND Previously, we have shown that radiofrequency (RF) renal denervation (RDN) reduces myocardial infarct size in a rat model of acute myocardial infarction (MI) and improves left ventricular (LV) function and vascular reactivity in the setting of heart failure following MI.OBJECTIVES The authors investigated the therapeutic efficacy of RF-RDN in a clinically relevant normotensive swine model of heart failure with reduced ejection fraction (HFrEF).METHODS Yucatan miniswine underwent 75 min of left anterior descending coronary artery balloon occlusion to induce MI followed by reperfusion (R) for 18 weeks. Cardiac function was assessed pre- and post-MI/R by transthoracic echocardiography and every 3 weeks for 18 weeks. HFrEF was classified by an LV ejection fraction