The threat of antimicrobial resistance in developing countries: causes and control strategies.
The threat of antimicrobial resistance in developing countries: causes and control strategies.
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DOI：
10.1186/s13756-017-0208-x
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发表时间：
2017
影响因子：
5.5
通讯作者：
Atabe AN
中科院分区：
文献类型：
--
作者：
Ayukekbong JA;Ntemgwa M;Atabe AN
发展中国家抗菌素耐药性（AMR）的原因很复杂，可能根源于卫生保健专业人员的做法和患者使用抗菌素的行为以及人群中抗菌素的供应链。其中一些因素可能包括不适当的处方实践、患者教育不足、诊断设施有限、未经授权销售抗菌剂、缺乏适当的药物监管机制以及非人类使用抗菌剂（如在动物生产中）。考虑到发展中国家的这些因素可能与发达国家的不同，发展中国家的干预努力需要处理这一背景，并侧重于世界这一地区特有的根源。在这里，我们描述了导致AMR威胁的这些寻求健康的行为和推动发展中国家AMR发展的医疗保健实践，我们讨论了疾病预防的替代方案以及其他值得探索的治疗方案。
The causes of antimicrobial resistance (AMR) in developing countries are complex and may be rooted in practices of health care professionals and patients’ behavior towards the use of antimicrobials as well as supply chains of antimicrobials in the population. Some of these factors may include inappropriate prescription practices, inadequate patient education, limited diagnostic facilities, unauthorized sale of antimicrobials, lack of appropriate functioning drug regulatory mechanisms, and non-human use of antimicrobials such as in animal production. Considering that these factors in developing countries may vary from those in developed countries, intervention efforts in developing countries need to address the context and focus on the root causes specific to this part of the world. Here, we describe these health-seeking behaviors that lead to the threat of AMR and healthcare practices that drive the development of AMR in developing countries and we discuss alternatives for disease prevention as well as other treatment options worth exploring.