Unilateral vibrissae stimulation during waking induces interhemispheric EEG asymmetry during subsequent sleep in the rat
Unilateral vibrissae stimulation during waking induces interhemispheric EEG asymmetry during subsequent sleep in the rat
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DOI：
10.1046/j.1365-2869.2000.00230.x
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发表时间：
2000-12-01
影响因子：
4.4
通讯作者：
Tobler, I
中科院分区：
文献类型：
--
作者：
Vyazovskiy, V;Borbély, AA;Tobler, I
为了验证睡眠是一个区域性的、依赖于使用的过程这一理论，大鼠在清醒时受到单侧感觉刺激。这是通过切断一侧的胡须来实现的，以减少对侧皮层的感觉输入。动物在丰富的环境中保持清醒6 h，以激活完整侧对侧的皮质。胡须被认为存在于对侧躯体感觉皮层的桶场中，在探索行为期间，它们的刺激导致投射区的特定激活。在睡眠剥夺后的6 h恢复期内，非快速眼动（NREM）睡眠EEG在0.75-6.0 Hz范围内的频谱功率表现出向对侧的完整胡须皮层的半球间移位。研究结果支持了睡眠具有区域性、使用依赖性的理论。
To test the theory that sleep is a regional, use-dependent process, rats were subjected to unilateral sensory stimulation during waking. This was achieved by cutting the whiskers on one side, in order to reduce the sensory input to the contralateral cortex. The animals were kept awake for 6 h in an enriched environment to activate the cortex contralateral to the intact side. Whiskers are known to be represented in the barrel field of the contralateral somatosensory cortex and their stimulation during exploratory behavior results in a specific activation of the projection area. In the 6 h recovery period following sleep deprivation, spectral power of the nonrapid eye-movement (NREM) sleep EEG in the 0.75-6.0 Hz range exhibited an interhemispheric shift towards the cortex that was contralateral to the intact whiskers. The results support the theory that sleep has a regional, use-dependent facet.