ION-SELECTIVE MEMBRANES WITH LOW PLASTICIZER CONTENT - ELECTROANALYTICAL CHARACTERIZATION AND BIOCOMPATIBILITY STUDIES
ION-SELECTIVE MEMBRANES WITH LOW PLASTICIZER CONTENT - ELECTROANALYTICAL CHARACTERIZATION AND BIOCOMPATIBILITY STUDIES
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DOI：
10.1002/jbm.820280509
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发表时间：
1994-05-01
期刊：
影响因子：
--
通讯作者：
ANDERSON, JM
中科院分区：
文献类型：
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作者：
LINDNER, E;COSOFRET, VV;ANDERSON, JM
高分子量聚（氯乙烯）和脂肪族聚氨酯（Tecoflex）为基础的离子选择性膜，与正常和减少量的增塑剂，以及没有增塑剂，进行了测试，其分析性能，其生物相容性，和细胞反应。膜的分析性质在宽范围的聚合物与增塑剂比率内没有显著变化。然而，减少增塑剂含量的膜具有更好的粘附性能，更少的阴离子干扰，延长的使用寿命，和更好的生物相容性。使用椎间融合器植入系统，结果表明Tecoflex膜中增塑剂重量百分比的增加与植入14天内宿主炎症反应的增加呈正相关。结果还表明，具有最常见膜组成（聚合物与增塑剂比例为1：2）的PVC和Tecoflex离子选择性膜表现出相似的急性炎症反应，但与Tecoflex膜相比，PVC膜引起的慢性炎症反应降低。(C)1994年，John Wiley and Sons，Inc.
High molecular weight poly(vinyl chloride) and aliphatic polyurethane (Tecoflex)-based ion selective membranes, with normal and reduced amounts of plasticizer, as well as without plasticizer, were tested with respect to their analytical properties, their biocompatibility, and cellular responses. The analytical properties of the membranes did not change significantly within a wide range of polymer to plasticizer ratios. However, the membranes with reduced plasticizer content had better adhesive properties, less anion interference, extended life time, and better biocompatibility. Using the cage implant system, the results showed that an increase of plasticizer weight percent in Tecoflex membranes correlated positively with the increase in host inflammatory response up to 14 days of implantation. The results also demonstrated that both PVC and Tecoflex-based ion-selective membranes with the most common membrane composition (1:2 polymer to plasticizer ratio) exhibited a similar acute inflammatory response, but the PVC-based membrane elicited a reduced chronic inflammatory response when compared with the Tecoflex-based membrane. (C) 1994 John Wiley and Sons, Inc.