Influence of elevated muscle temperature on metabolism during intense, dynamic exercise
Influence of elevated muscle temperature on metabolism during intense, dynamic exercise
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DOI：
10.1152/ajpregu.1996.271.5.r1251
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发表时间：
1996-11-01
影响因子：
2.8
通讯作者：
Hargreaves, M
中科院分区：
文献类型：
--
作者：
Febbraio, MA;Carey, MF;Hargreaves, M
本研究探讨了运动过程中肌肉温度升高对肌肉代谢的影响。7名活跃但未经训练的男性在估计需要115%最大摄氧量（VO 2）的工作量下完成了2分钟的两次自行车测力计试验，无论是未经预处理（CT）还是在运动前（HT）将大腿包裹在加热毯中60分钟。HT增加了（P < 0.01）肌肉温度（T-m），并导致运动前（Delta = 1.9 +/- 0.1摄氏度，P < 0.01）和运动后（Delta = 0.6 +/- 0.2摄氏度，P < 0.05）两次试验之间的T-m差异。HT不影响直肠温度或血浆儿茶酚胺。此外，这些参数在运动前后CT和HT之间没有差异。HT和CT之间未观察到腺嘌呤核苷酸（ATP、ADP、AMP）或其降解产物（肌苷5 '-单磷酸、氨）、乳酸盐、糖原、磷酸肌酸或肌酸的静息肌内浓度存在差异。运动过程中，HT组ATP降解、肌苷酸和氨积累量均高于CT组（P < 0.05）。虽然两组运动前糖原和乳酸浓度无差异，但运动后HT组乳酸浓度高于CT组（P < 0.05），糖原浓度低于CT组（P < 0.05）。此外，HT组的肌糖原利用率高于HT组（P < 0.05）。它的结论是，一个升高的T-M本身增加肌肉糖原分解，糖酵解，和高能量磷酸盐降解运动过程中。这些变化可能是由于运动引起的ATP周转率增加和/或ATP再合成的无氧/有氧贡献的变化。
This study examined the effects of elevated muscle temperature on muscle metabolism during exercise. Seven active but untrained men completed two cycle ergometer trials for 2 min at a workload estimated to require 115% maximal oxygen uptake (VO2) either without pretreatment (CT) or after having their thigh wrapped in a heating blanket for 60 min before exercise (HT). HT increased (P < 0.01) muscle temperature (T-m) and resulted in a difference in T-m between the two trials before (Delta = 1.9 +/- 0.1 degrees C, P < 0.01) and after exercise (Delta = 0.6 +/- 0.2 degrees C, P < 0.05). HT did not affect rectal temperature or plasma catecholamines. In addition, these parameters were not different between CT and HT either before or after exercise. No differences in resting intramuscular concentrations of the adenine nucleotides (ATP, ADP, AMP) or their degradation products (inosine 5'-monophosphate, ammonia), lactate, glycogen, creatine phosphate, or creatine were observed between HT and CT. During exercise, the magnitude of ATP degradation and inosine 5'-monophosphate and ammonia accumulation was higher (P < 0.05) in HT compared with CT. Although preexercise concentrations of glycogen and lactate were not different between the two trials, postexercise lactate concentration was higher (P < 0.05) and glycogen lower (P < 0.05) in HT compared with CT. In addition, net muscle glycogen use was higher (P < 0.05) in HT. It is concluded that an elevated T-m per se increases muscle glycogenolysis, glycolysis, and high energy phosphate degradation during exercise. These alterations may be the result of an increased rate of ATP turnover associated with the exercise and/or changes in the anaerobic/aerobic contribution to ATP resynthesis.