Association of elevated alpha 1-antichymotrypsin with cognitive impairment in a prospective study of the very old.
Association of elevated alpha 1-antichymotrypsin with cognitive impairment in a prospective study of the very old.
复制标题
在一项针对老年人的前瞻性研究中，α1-抗胰凝乳蛋白酶升高与认知障碍之间存在关联。
DOI：
10.1176/ajp.155.5.698
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Mohs,RC
中科院分区：
文献类型：
--
作者：
Gabriel,SM;Marin,DB;Aisen,PS;Lantz,M;Altstiel,LD;Davis,KL;Mohs,RC
作者调查了两种急性时相蛋白α1-抗糜蛋白酶（ACT）和α2-巨球蛋白（MAC）的浓度与老年人认知功能障碍的关系。认知功能障碍用简易精神状态量表进行评估。ACT的浓度越高，认知功能障碍越严重，这可以通过简易精神状态量表评分越低来反映。这种关系并不存在MAC.CONCLUSIONSThese数据扩展以前的报告，阿尔茨海默氏病患者有更大的ACT浓度在他们的血液中，通过证明在一个诊断不同的疗养院人口之间的关系血清ACT和精神状态。精神状态受损患者血清ACT升高可能反映了脑急性期反应。
OBJECTIVEThe authors investigated the relationships between concentrations of two acute-phase proteins, α1-antichymotrypsin (ACT) and α2-macroglobulin (MAC), and cognitive impairment in the very old.METHODConcentrations of ACT and MAC were determined in a prospective study using sera from medically stable elderly nursing home residents. Cognitive impairment was assessed with the Mini-Mental State.RESULTSConcentrations of ACT were associated with greater cognitive impairment, as reflected by lower Mini-Mental State scores. This relationship did not exist for MAC.CONCLUSIONSThese data extend previous reports that patients with Alzheimer's disease have greater concentrations of ACT in their blood by demonstrating in a diagnostically diverse nursing home population a relationship between serum ACT and mental status. Elevated serum ACT in patients with compromised mental status may reflect a cerebral acute-phase response.