Schizophrenia genetics: dysbindin under the microscope
Schizophrenia genetics: dysbindin under the microscope
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DOI：
10.1016/j.tins.2004.06.004
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发表时间：
2004-09-01
影响因子：
15.9
通讯作者：
Blake, DJ
中科院分区：
文献类型：
--
作者：
Benson, MA;Sillitoe, RV;Blake, DJ
众所周知，遗传因素在很大程度上影响了个体对精神分裂症的易感性。Straub、Kendler及其同事发表了几篇文章中的第一篇，证明了精神分裂症与编码肌营养不良蛋白结合蛋白dysbindin的基因之间的遗传关联。虽然没有发现dysbindin基因的突变，但最近在独立样本中鉴定出的特定风险单倍型提供了进一步的证据，表明dysbindin可能是精神分裂症易感基因。
It is well established that genetic factors strongly contribute to the susceptibility of an individual to schizophrenia. Straub, Kendler and colleagues have published the first of several articles demonstrating a genetic association between schizophrenia and the gene encoding the dystrobrevin-binding protein dysbindin. Although no mutations in the dysbindin gene have been found, the recent identification of a specific risk haplotype in independent samples provides further evidence that dysbindin is a possible schizophrenia susceptibility gene.