Stress exacerbates pancreatic cancer both directly and indirectly by creating an immunosuppressive environment
Stress exacerbates pancreatic cancer both directly and indirectly by creating an immunosuppressive environment
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DOI：
10.1002/jhbp.1295
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发表时间：
2022-12
期刊：
影响因子：
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通讯作者：
T. Ikeda;T. Adachi;Takayuki Tanaka;Daisuke Miyamoto;H. Imamura;H. Matsushima;Kazuo Yamamoto;M. Hidaka;K. Kanetaka;S. Eguchi
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文献类型：
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作者：
T. Ikeda;T. Adachi;Takayuki Tanaka;Daisuke Miyamoto;H. Imamura;H. Matsushima;Kazuo Yamamoto;M. Hidaka;K. Kanetaka;S. Eguchi
应激引起的交感神经刺激会加重各种实体瘤，包括胰腺癌（PCa）。癌症和免疫之间的关系已经被提出;然而，关于神经刺激对免疫和癌症的影响的信息有限。我们的目的是调查参与交感神经刺激免疫细胞和PCa使用束缚应激小鼠模型的影响。
Sympathetic nerve stimulation by stress exacerbates various solid tumors, including pancreatic cancer (PCa). The relationship between cancer and immunity has been suggested; however, there is limited information about the effects of nerve stimulation on immunity and cancer. We aimed to investigate the involvement of sympathetic nerve stimulation in immune cells and its effects on PCa using a restraint stress mouse model.