Ion channel and receptor mechanisms of bladder afferent nerve sensitivity
Ion channel and receptor mechanisms of bladder afferent nerve sensitivity
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膀胱传入神经敏感性的离子通道和受体机制
DOI：
10.1016/j.autneu.2009.07.003
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发表时间：
2010-02-16
影响因子：
2.7
通讯作者：
Rong, Weifang
中科院分区：
文献类型：
--
作者：
Sun, Biying;Li, Qian;Rong, Weifang
膀胱的感觉神经由小直径的A、5和C纤维组成，这些纤维在腹下神经和盆神经中行进。神经解剖学研究揭示了膀胱壁内复杂的神经网络。体外和体内的电生理记录揭示了几种不同类别的传入纤维，其可以发出广泛的膀胱刺激信号，包括生理性膀胱充盈、有害膨胀、寒冷、化学刺激和炎症。强调膀胱传入末梢中的机械感觉转导的确切机制仍然不明确;然而，广泛的离子通道（例如，TTX抗性Na+通道、Kv通道和超极化激活的环核苷酸门控阳离子通道）和受体（例如，TRPV 1、TRPM 8、TRPA 1、P2 X（2/3）等）在膀胱传入终末被鉴定出参与传入信号的产生和调节。实验研究表明，这些离子通道和受体的表达和/或功能可能会在动物模型和膀胱过度活动症和疼痛性疾病患者中发生改变。其中一些离子通道和受体可能是膀胱疾病的潜在治疗靶点。(C)2009 Elsevier B. V.保留所有权利。
Sensory nerves of the urinary bladder consist of small diameter A,5 and C fibers running in the hypogastic and pelvic nerves. Neuroanatomical studies have revealed a complex neuronal network within the bladder wall. Electrophysiological recordings in vitro and in vivo have revealed several distinct classes of afferent fibers that may signal a wide range of bladder stimulations including physiological bladder filling, noxious distension, cold, chemical irritation and inflammation. The exact mechanisms that underline mechanosensory transduction in bladder afferent terminals remain ambiguous; however, a wide range of ion channels (e.g., TTX-resistant Na+ channels, Kv channels and hyperpolarization-activated cyclic nucleotidegated cation channels) and receptors (e.g., TRPV1, TRPM8, TRPA1, P2X(2/3), etc) have been identified at bladder afferent terminals and implicated in the generation and modulation of afferent signals. Experimental investigations have revealed that expression and/or function of these ion channels and receptors may be altered in animal models and patients with overactive and painful bladder disorders. Some of these ion channels and receptors may be potential therapeutic targets for bladder diseases. (C) 2009 Elsevier B.V. All rights reserved.