Fe3O4/Ag/Bi2MoO6 Photoactivatable Nanozyme for Self-Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy
Fe3O4/Ag/Bi2MoO6 Photoactivatable Nanozyme for Self-Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy
复制标题
Fe3O4/Ag/Bi2MoO6 光活化纳米酶用于自我补充和可持续级联纳米催化癌症治疗
DOI：
10.1002/adma.202106996
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发表时间：
2021-10-19
影响因子：
29.4
通讯作者：
Dong, Xiaochen
中科院分区：
文献类型：
--
作者：
Cao, Changyu;Zou, Hai;Dong, Xiaochen
基于纳米酶的催化癌症治疗最近引起了很大的兴趣。然而，目前的纳米酶的类型是有限的，它们的效率通常是妥协的，在肿瘤微环境（TME）中是不可持续的。因此，涉及额外治疗剂的联合治疗通常是必要的，并且所产生的并发症可能危及实际可行性。在此，一个前所未有的“所有在一个”Fe 3 O 4/Ag/Bi 2 MoO 6纳米粒子（FAB NP）的合理设计，以实现协同的化学动力学，光动力学，光热治疗与磁共振，光声，光热成像的指导。基于其多种纳米酶活性（模拟过氧化物酶、过氧化氢酶、超氧化物歧化酶、谷胱甘肽氧化酶）和光动力学性质，在TME中实现并维持级联纳米催化反应以获得出色的治疗结果。纳米催化反应和纳米酶活性之间的耦合所产生的颗粒内的相互作用，可持续性和自我补充的工作机制被仔细揭示，提供新的见解设计的新型纳米酶的纳米催化治疗具有高效率，良好的特异性，和低副作用。
Catalytic cancer therapy based on nanozymes has recently attracted much interest. However, the types of the current nanozymes are limited and their efficiency is usually compromised and not sustainable in the tumor microenvironment (TME). Therefore, combination therapy involving additional therapeutics is often necessary and the resulting complication may jeopardize the practical feasibility. Herein, an unprecedented "all-in-one" Fe3O4/Ag/Bi2MoO6 nanoparticle (FAB NP) is rationally devised to achieve synergistic chemodynamic, photodynamic, photothermal therapy with guidance by magnetic resonance, photoacoustic, and photothermal imaging. Based on its manifold nanozyme activities (mimicking peroxidase, catalase, superoxide dismutase, glutathione oxidase) and photodynamic property, cascaded nanocatalytic reactions are enabled and sustained in TME for outstanding therapeutic outcomes. The working mechanisms underlying the intraparticulate interactions, sustainability, and self-replenishment arising from the coupling between the nanocatalytic reactions and nanozyme activities are carefully revealed, providing new insights into the design of novel nanozymes for nanocatalytic therapy with high efficiency, good specificity, and low side effects.