Exosome: emerging biomarker in breast cancer.
Exosome: emerging biomarker in breast cancer.
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外泌体：乳腺癌的新兴生物标志物
DOI：
10.18632/oncotarget.16684
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发表时间：
2017-06-20
期刊：
影响因子：
--
通讯作者：
Zhou J
中科院分区：
文献类型：
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作者：
Jia Y;Chen Y;Wang Q;Jayasinghe U;Luo X;Wei Q;Wang J;Xiong H;Chen C;Xu B;Hu W;Wang L;Zhao W;Zhou J
外泌体是由多种细胞类型释放的纳米级膜囊泡，被认为在细胞间通讯中起重要作用。在乳腺癌中，通过各种生物活性分子（如蛋白质和mrna）的水平转移，外泌体正在成为局部和全身细胞间致癌信息的介质，并在癌症进展中发挥重要作用。本文综述了外泌体参与乳腺癌发病机制（包括肿瘤起始、侵袭转移、血管生成、免疫系统调节和肿瘤微环境）和肿瘤治疗耐药的最新知识和概念。此外，还讨论了外泌体作为乳腺癌诊断和治疗生物标志物的潜在用途。
Exosomes are nano-sized membrane vesicles released by a variety of cell types, and are thought to play important roles in intercellular communications. In breast cancer, through horizontal transfer of various bioactive molecules, such as proteins and mRNAs, exosomes are emerging as local and systemic cell-to-cell mediators of oncogenic information and play an important role on cancer progression. This review outlines the current knowledge and concepts concerning the exosomes involvement in breast cancer pathogenesis (including tumor initiation, invasion and metastasis, angiogenesis, immune system modulation and tumor microenvironment) and cancer therapy resistance. Moreover, the potential use of exosomes as promising diagnostic and therapeutic biomarkers in breast cancer are also discussed.