QUANTITATIVE STUDIES OF ADOPTIVE IMMUNOLOGICAL MEMORY IN MICE .1. AN AGE-DEPENDENT BARRIER TO SYNGENEIC TRANSPLANTATION
QUANTITATIVE STUDIES OF ADOPTIVE IMMUNOLOGICAL MEMORY IN MICE .1. AN AGE-DEPENDENT BARRIER TO SYNGENEIC TRANSPLANTATION
复制标题
DOI：
10.1084/jem.124.1.1
复制
发表时间：
1966-01-01
影响因子：
15.3
通讯作者：
CELADA, F
中科院分区：
文献类型：
--
作者：
CELADA, F
从小鼠脾脏悬浮并转移到相同基因型的完整动物中的抗体形成细胞面临严重影响其植入和/或功能的能力的屏障。在模型系统中定量研究了这种现象，该系统利用小鼠中人血清白蛋白的免疫原性，允许在不受宿主自身反应性干扰的情况下跟踪转移细胞的次级反应。同基因移植的屏障被发现是放射敏感的（500 R X射线对受体消除了它，并确保供体细胞的最佳功能条件），与涉及快速分裂细胞群的其他哺乳动物系统的数量级相同，并取决于受体的年龄：它的线性上升记录从出生时（当[image] 50%的最大免疫能力的转移表达）到2个月的年龄（[image] 1%）。这些研究结果的免疫反应和细胞的生长和分化的意义进行了讨论。
Antibody-forming cells suspended from a mouse spleen and transferred to intact animals of the same genotype face a barrier which severely affects their capacity to implant and/or to function. This phenomenon was quantitatively studied in a model system which, ultilizing the immunogenic properties of human serum albumin in mice, allows the secondary response of the transferred cells to be followed without interference from the host''s own reactivity. The barrier to syngeneic transplantation was found to be radiosensitive (500 R X-rays to the recipient abolishes it and insures optimal functional conditions to the donor cells) in the same order of magnitude of other mammalian systems involving rapidly dividing cell populations and to depend upon the age of the recipient: its linear rise is documented from birth time (when[image] 50% of the maximal immune capacity of the transfer is expressed) to the age of 2 months ([image] 1%). The significance of these findings to the immune response and to cell growth and differentiation is discussed.