13C and 15N chemical shift anisotropy of ampicillin and penicillin-V studied by 2D-PASS and CP/MAS NMR
13C and 15N chemical shift anisotropy of ampicillin and penicillin-V studied by 2D-PASS and CP/MAS NMR
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DOI：
10.1006/jmre.1998.1576
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发表时间：
1998-11-01
影响因子：
2.2
通讯作者：
Levitt, MH
中科院分区：
文献类型：
--
作者：
Antzutkin, ON;Lee, YK;Levitt, MH
用二维相位调整自旋边带（2D-PASS）和常规CP/MAS实验测定了氨苄青霉素和青霉素-V两种抗生素分子中所有C-13和N-15位化学位移张量的主值。使用Mathematica程序评估了C-13和N-15化学位移各向异性（CSA）及其置信限。CSA值表明在氨苄青霉素的情况下α-甲基C-13位点的修订分配。我们推测之间的关系的许多C-13和N-15网站和β-内酰胺环构象的化学位移主值。(C)北京：科学出版社.
The principal values of the chemical shift tensors of all C-13 and N-15 sites in two antibiotics, ampicillin and penicillin-V, were determined by 2-dimensional phase adjusted spinning sideband (2D-PASS) and conventional CP/MAS experiments. The C-13 and N-15 chemical shift anisotropies (CSA), and their confidence limits, were evaluated using a Mathematica program. The CSA values suggest a revised assignment of the a-methyl C-13 sites in the case of ampicillin. We speculate on a relationship between the chemical shift principal values of many of the C-13 and N-15 sites and the beta-lactam ring conformation. (C) 1998 Academic Press.