Ischemia-reperfusion in the adult mouse heart Influence of age
Ischemia-reperfusion in the adult mouse heart Influence of age
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DOI：
10.1016/s0531-5565(99)00031-5
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发表时间：
1999-08-01
影响因子：
3.9
通讯作者：
Wei, JY
中科院分区：
文献类型：
--
作者：
Azhar, G;Gao, W;Wei, JY
小鼠心脏在缺血-再灌注后与年龄相关的变化尚未得到很好的表征。为了验证年龄增大与心肌缺血/再灌注损伤易感性增加的假设，我们研究了青年和老年小鼠的心脏，在青年(6-8月)和老年(22-24月)C57BL/6小鼠中，我们进行了冠状动脉左前降支结扎，使心脏缺血45min，然后改变15min、1h、4h和24h的再灌流时间，我们发现青年和老年心脏的梗塞面积有显著的年龄差异。在收缩带坏死、肌纤维撕裂、DNA断裂和线粒体破坏方面，老年人的心脏也受到了更大的损害。因此，陈旧的心脏在缺血再灌注后更容易受到损伤。这可能部分是由于与年龄相关的冠脉循环和侧支循环减少，以及其他因素。(C)1999 Elsevier Science Inc.保留所有权利。
Age-related changes in the mouse heart after ischemia-reperfusion have not been well characterized. To test the hypothesis that advanced age was associated with increased susceptibility to myocardial injury after ischemia/reperfusion, we studied the hearts of young adult and old mice, In young adult (6-8 months) and aged (22-24 months) C57 BL/6 mice, we performed left anterior descending coronary artery ligation and subjected the hearts to 45 min of ischemia followed by varying: periods of reperfusion of 15 min, 1 h, 4 h, and 24 h. We found that there was a significant age difference in the size of the infarct between the young adult and old hearts. There was also greater damage in the old hearts in terms of contraction band necrosis, myofiber tears, DNA fragmentation, and mitochondrial disruption. Thus, the old heart is more susceptible to injury after ischemia-reperfusion. This may be partly due to an age-associated decrease in coronary circulation and collateral flow, as well as other factors. (C) 1999 Elsevier Science Inc. All rights reserved.