Neuroprotective effects of a novel NMDA antagonist, Gacyclidine, after experimental contusive spinal cord injury in adult rats
Neuroprotective effects of a novel NMDA antagonist, Gacyclidine, after experimental contusive spinal cord injury in adult rats
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DOI：
10.1016/s0006-8993(00)02581-6
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发表时间：
2000-08-25
期刊：
影响因子：
2.9
通讯作者：
Ohanna, F
中科院分区：
文献类型：
--
作者：
Gaviria, M;Privat, A;Ohanna, F
本研究的目的是分析新型 NMDA 拮抗剂加环利定在实验性脊髓损伤后神经保护的最佳时间窗口，包括其功能、组织病理学和电生理学效应。该分子已经证明了其减少缺血性病变程度的能力，目前正在脊髓损伤的临床试验中进行实验。在本研究中，大鼠脊髓受到挫伤性损伤，损伤后10、30、60和120分钟给予生理盐水或1 mg/kg加环利定静脉注射。损伤后第1、7和18天评估运动评分的时程，并在第20天测定体感诱发电位。然后处死动物并测量脊髓横截面积（损伤中心、损伤上方和下方）。步行恢复较好（P
The aim of this study was to analyze the optimal time-window for neuroprotection by a novel NMDA antagonist, Gacyclidine, after experimental spinal cord injury, in terms of its functional, histopathological and electrophysiological effects. This molecule has already demonstrated its capacity for reducing the extent of an ischemic lesion and is currently experimented in a clinical trial of spinal cord injury. In this study, the spinal cord of rats was damaged by a contusive method and the animals were treated by saline or 1 mg/kg of Gacyclidine i.v., 10, 30, 60 and 120 min after injury. The time-course of the motor score was evaluated on days 1, 7 and 18 after injury, and somatosensory evoked potentials were determined on day 20. The animals were then killed and the cross-sectional area of the spinal cord (at the epicenter of the injury, above and below the injury), was measured. Walking recovery was better (P