Chemicals, Nutrition, and Autism Spectrum Disorder: A Mini-Review.
Chemicals, Nutrition, and Autism Spectrum Disorder: A Mini-Review.
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DOI：
10.3389/fnins.2016.00174
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发表时间：
2016
影响因子：
4.3
通讯作者：
Tani Y
中科院分区：
文献类型：
--
作者：
Fujiwara T;Morisaki N;Honda Y;Sampei M;Tani Y
自闭症谱系障碍（ASD）患病率的快速增长表明，接触化学物质可能会影响ASD的发展。因此，我们回顾了以下化学物质，营养物质的文献，以研究它们与ASD的关系：(1)烟雾/烟草，(2)酒精，(3)空气污染，(4)农药，(5)内分泌干扰化学物质，(6)重金属，(7)微量营养素，(8)脂肪酸，(9)父母肥胖作为特定化学物质积累或营养状况的代表。几种化学物质暴露，如空气污染（例如，特定物质2.5）、农药、双酚A、邻苯二甲酸盐、汞和营养缺乏，如叶酸、维生素D或脂肪酸，可能与自闭症谱系障碍的风险增加有关，而其他传统的风险因素，如吸烟/烟草、酒精或多氯联苯，与自闭症谱系障碍的关联较小。需要进一步的研究来积累证据，证明不同剂量和人群的化学物质暴露与营养缺乏和自闭症之间的关系。
The rapid increase of the prevalence of autism spectrum disorder (ASD) suggests that exposure to chemicals may impact the development of ASD. Therefore, we reviewed literature on the following chemicals, nutrient to investigate their association with ASD: (1) smoke/tobacco, (2) alcohol, (3) air pollution, (4) pesticides, (5) endocrine-disrupting chemicals, (6) heavy metals, (7) micronutrients, (8) fatty acid, and (9) parental obesity as a proxy of accumulation of specific chemicals or nutritional status. Several chemical exposures such as air pollution (e.g., particular matter 2.5), pesticides, bisphenol A, phthalates, mercury, and nutrition deficiency such as folic acid, vitamin D, or fatty acid may possibly be associated with an increased risk of ASD, whereas other traditional risk factors such as smoking/tobacco, alcohol, or polychlorinated biphenyls are less likely to be associated with ASD. Further research is needed to accumulate evidence on the association between chemical exposure and nutrient deficiencies and ASD in various doses and populations.